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FOXO transcription factors : from cell fate decisions to regulation of human female reproduction

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Brosens, Jan J., Wilson, Miranda S. C. and Lam, Eric W.-F. (2009) FOXO transcription factors : from cell fate decisions to regulation of human female reproduction. In: Forkhead Transcription Factors : vital elements in biology and medicine. Advances in experimental medicine and biology, Vol.665 . New York ; Austin, Tex.: Springer Science+Business Media ; Landes Bioscience, pp. 227-241. ISBN 9781441915993

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Official URL: http://dx.doi.org/10.1007/978-1-4419-1599-3_17

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Abstract

All key reproductive events in the human ovary and uterus, including follicle activation, ovulation, implantation, decidualization, luteolysis and menstruation, are dependent upon profound tissue remodelling, characterised by cyclical waves of cell proliferation, differentiation, apoptosis, tissue breakdown and regeneration. FOXO transcription factors, an evolutionarily conserved subfamily of the forkhead transcription factors, have emerged as master regulators ofcell fate decision capable ofintegrating avariety ofstress, growth factor and cytokine signaling pathways with the transcription machinery. The ability of FOXOs to regulate seemingly opposing cellular responses, ranging from cell cycle arrest and oxidative stress responses to differentiation and apoptosis, renders these transcription factors indispensable for cyclic tissue remodelling in female reproduction. Conversely, perturbations in the expression or activity of FOXO transcription factors are increasingly linked to common reproductive disorders, such as pregnancy loss, endometriosis, endometrial cancer and primary ovarian insufficiency.

Item Type: Book Item
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016)
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Series Name: Advances in experimental medicine and biology
Publisher: Springer Science+Business Media ; Landes Bioscience
Place of Publication: New York ; Austin, Tex.
ISBN: 9781441915993
ISSN: 0065-2598
Book Title: Forkhead Transcription Factors : vital elements in biology and medicine
Official Date: 2009
Dates:
DateEvent
2009Published
Volume: Vol.665
Number of Pages: 269
Page Range: pp. 227-241
DOI: 10.1007/978-1-4419-1599-3_17
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Related URLs:
  • http://webcat.warwick.ac.uk/record=b2509...

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