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FOXO transcription factors : from cell fate decisions to regulation of human female reproduction
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Brosens, Jan J., Wilson, Miranda S. C. and Lam, Eric W.-F. (2009) FOXO transcription factors : from cell fate decisions to regulation of human female reproduction. In: Forkhead Transcription Factors : vital elements in biology and medicine. Advances in experimental medicine and biology, Vol.665 . New York ; Austin, Tex.: Springer Science+Business Media ; Landes Bioscience, pp. 227-241. ISBN 9781441915993
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Official URL: http://dx.doi.org/10.1007/978-1-4419-1599-3_17
Abstract
All key reproductive events in the human ovary and uterus, including follicle activation, ovulation, implantation, decidualization, luteolysis and menstruation, are dependent upon profound tissue remodelling, characterised by cyclical waves of cell proliferation, differentiation, apoptosis, tissue breakdown and regeneration. FOXO transcription factors, an evolutionarily conserved subfamily of the forkhead transcription factors, have emerged as master regulators ofcell fate decision capable ofintegrating avariety ofstress, growth factor and cytokine signaling pathways with the transcription machinery. The ability of FOXOs to regulate seemingly opposing cellular responses, ranging from cell cycle arrest and oxidative stress responses to differentiation and apoptosis, renders these transcription factors indispensable for cyclic tissue remodelling in female reproduction. Conversely, perturbations in the expression or activity of FOXO transcription factors are increasingly linked to common reproductive disorders, such as pregnancy loss, endometriosis, endometrial cancer and primary ovarian insufficiency.
| Item Type: | Book Item | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Series Name: | Advances in experimental medicine and biology | ||||
| Publisher: | Springer Science+Business Media ; Landes Bioscience | ||||
| Place of Publication: | New York ; Austin, Tex. | ||||
| ISBN: | 9781441915993 | ||||
| ISSN: | 0065-2598 | ||||
| Book Title: | Forkhead Transcription Factors : vital elements in biology and medicine | ||||
| Official Date: | 2009 | ||||
| Dates: |
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| Volume: | Vol.665 | ||||
| Number of Pages: | 269 | ||||
| Page Range: | pp. 227-241 | ||||
| DOI: | 10.1007/978-1-4419-1599-3_17 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Related URLs: |
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