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Fyn kinase function in lipid utilization : a new upstream regulator of AMPK activity?
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Vatish, Manu, Yamada, Eijiro, Pessin, Jeffrey E. and Bastie, Claire C.. (2009) Fyn kinase function in lipid utilization : a new upstream regulator of AMPK activity? Archives of Physiology and Biochemistry, Vol.115 (No.4). pp. 191-198. ISSN 1381-3455
Full text not available from this repository.Abstract
The balance of cellular energy levels in response to changes of nutrient availability, stress stimuli or exercise is a critical step in maintaining tissue and whole body homeostasis. Disruption of this balance is associated with various pathologies, including the metabolic syndrome. Recently, accumulating evidence has demonstrated that the AMP-activated protein kinase (AMPK) plays a central role in sensing changes in energy levels. The regulation of AMPK activity is currently the subject of significant investigation since this enzyme is a potential therapeutic target in both metabolic disorders and tumorigenesis. In this review, we present novel evidence of crosstalk between Fyn, one member of the Src kinase family, and AMPK.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Warwick Medical School > Reproductive Health Faculty of Medicine > Warwick Medical School |
| Journal or Publication Title: | Archives of Physiology and Biochemistry |
| Publisher: | Informa Healthcare |
| ISSN: | 1381-3455 |
| Date: | October 2009 |
| Volume: | Vol.115 |
| Number: | No.4 |
| Page Range: | pp. 191-198 |
| Identification Number: | 10.1080/13813450903164348 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/45710 |
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