Fyn kinase function in lipid utilization : a new upstream regulator of AMPK activity?
Vatish, Manu, Yamada, Eijiro, Pessin, Jeffrey E. and Bastie, Claire C.. (2009) Fyn kinase function in lipid utilization : a new upstream regulator of AMPK activity? Archives of Physiology and Biochemistry, Vol.115 (No.4). pp. 191-198. ISSN 1381-3455Full text not available from this repository.
The balance of cellular energy levels in response to changes of nutrient availability, stress stimuli or exercise is a critical step in maintaining tissue and whole body homeostasis. Disruption of this balance is associated with various pathologies, including the metabolic syndrome. Recently, accumulating evidence has demonstrated that the AMP-activated protein kinase (AMPK) plays a central role in sensing changes in energy levels. The regulation of AMPK activity is currently the subject of significant investigation since this enzyme is a potential therapeutic target in both metabolic disorders and tumorigenesis. In this review, we present novel evidence of crosstalk between Fyn, one member of the Src kinase family, and AMPK.
|Item Type:||Journal Article|
|Subjects:||R Medicine > R Medicine (General)|
|Divisions:||Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Reproductive Health
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Archives of Physiology and Biochemistry|
|Official Date:||October 2009|
|Page Range:||pp. 191-198|
|Access rights to Published version:||Restricted or Subscription Access|
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