Vatish, Manu, Yamada, Eijiro, Pessin, Jeffrey E. and Bastie, Claire C.. (2009) Fyn kinase function in lipid utilization : a new upstream regulator of AMPK activity? Archives of Physiology and Biochemistry, Vol.115 (No.4). pp. 191-198. ISSN 1381-3455

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Abstract

The balance of cellular energy levels in response to changes of nutrient availability, stress stimuli or exercise is a critical step in maintaining tissue and whole body homeostasis. Disruption of this balance is associated with various pathologies, including the metabolic syndrome. Recently, accumulating evidence has demonstrated that the AMP-activated protein kinase (AMPK) plays a central role in sensing changes in energy levels. The regulation of AMPK activity is currently the subject of significant investigation since this enzyme is a potential therapeutic target in both metabolic disorders and tumorigenesis. In this review, we present novel evidence of crosstalk between Fyn, one member of the Src kinase family, and AMPK.

Item Type:	Journal Article
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Reproductive Health Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Archives of Physiology and Biochemistry
Publisher:	Informa Healthcare
ISSN:	1381-3455
Official Date:	October 2009
Volume:	Vol.115
Number:	No.4
Page Range:	pp. 191-198
Identification Number:	10.1080/13813450903164348
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/45710

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