Parekh, Vimal (2011) Asymmetric transfer hydrogenation reductions using tethered ruthenium (II) catalysts. PhD thesis, University of Warwick.

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Abstract

By asymmetric transfer hydrogenation, substituted quinolines, which are generally regarded as challenging substrates for reduction, were successfully converted into tetrahydroquinolines using "tethered" Ru(II) and "tethered" Rh(III) complexes in formic acid/triethylamine. An ether-linked "tethered" catalyst was successfully synthesized through a sequence that avoids the use of a Birch reduction for the formation of a 1,4-cyclohexadiene moiety. The ether link is incorporated between the basic amine of the ligand and the η6- arene ring, giving results comparable to the alkyl-"tethered" complexes. N-alkylated complexes containing a straight-chain substituent attached to a hydroxyl, ether or ester function can act as effective catalysts for the reduction of ketones, and also contains the required functionality for attachment of the catalyst to a heterogeneous support.

Item Type:	Thesis or Dissertation (PhD)
Subjects:	Q Science > QD Chemistry
Library of Congress Subject Headings (LCSH):	Hydrogenation, Quinoline, Ruthenium, Metal catalysts
Date:	September 2011
Institution:	University of Warwick
Theses Department:	Department of Chemistry
Thesis Type:	PhD
Publication Status:	Unpublished
Supervisor(s)/Advisor:	Wills, Martin
Sponsors:	Engineering and Physical Sciences Research Council (EPSRC) ; Dr. Reddy's Laboratories
Extent:	vii, 253 leaves : ill.
Language:	eng
URI:	http://wrap.warwick.ac.uk/id/eprint/45754

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