Asymmetric transfer hydrogenation reductions using tethered ruthenium (II) catalysts
Parekh, Vimal (2011) Asymmetric transfer hydrogenation reductions using tethered ruthenium (II) catalysts. PhD thesis, University of Warwick.
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By asymmetric transfer hydrogenation, substituted quinolines, which are generally regarded as challenging substrates for reduction, were successfully converted into tetrahydroquinolines using "tethered" Ru(II) and "tethered" Rh(III) complexes in formic acid/triethylamine. An ether-linked "tethered" catalyst was successfully synthesized through a sequence that avoids the use of a Birch reduction for the formation of a 1,4-cyclohexadiene moiety. The ether link is incorporated between the basic amine of the ligand and the η6- arene ring, giving results comparable to the alkyl-"tethered" complexes. N-alkylated complexes containing a straight-chain substituent attached to a hydroxyl, ether or ester function can act as effective catalysts for the reduction of ketones, and also contains the required functionality for attachment of the catalyst to a heterogeneous support.
|Item Type:||Thesis or Dissertation (PhD)|
|Subjects:||Q Science > QD Chemistry|
|Library of Congress Subject Headings (LCSH):||Hydrogenation, Quinoline, Ruthenium, Metal catalysts|
|Institution:||University of Warwick|
|Theses Department:||Department of Chemistry|
|Sponsors:||Engineering and Physical Sciences Research Council (EPSRC) ; Dr. Reddy's Laboratories|
|Extent:||vii, 253 leaves : ill.|
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