Quantitative asymmetric reaction kinetics
Rushworth, Philip John (2011) Quantitative asymmetric reaction kinetics. PhD thesis, University of Warwick.Full text not available from this repository.
Official URL: http://webcat.warwick.ac.uk/record=b2565547~S1
The comparison of catalysts for producing chiral materials is of vital importance in the improvement of reaction scope and efficacy. Here we describe a new method of analysing the kinetics of the stereodetermining steps in asymmetric reactions by performing ligand/catalyst competition experiments against an internal standard and measuring the enantiomeric excess obtained at a variety of ratios of ligand/catalyst to internal standard. From these enantiomeric excess measurements, we can establish the relative rate of reaction between the ligand/catalyst systems and the internal standard, allowing us to make indirect comparisons of the rates at which the ligands/catalysts perform the reaction. Here we take this method and apply it to three common synthetic procedures: the Sharpless asymmetric dihydroxylation, the asymmetric Michael addition of malonates to nitroalkenes and palladium catalysed asymmetric allylation reaction.
|Item Type:||Thesis or Dissertation (PhD)|
|Subjects:||Q Science > QD Chemistry|
|Library of Congress Subject Headings (LCSH):||Enantioselective catalysis, Chemical kinetics|
|Institution:||University of Warwick|
|Theses Department:||Department of Chemistry|
|Sponsors:||Engineering and Physical Sciences Research Council (EPSRC)|
|Extent:||x, 218 leaves : ill., charts|
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