Kajihara, Takeshi, Uchino, Satomi, Suzuki, Motoharu, Itakura, Atsuo, Brosens, Jan J. and Ishihara, Osamu. (2009) Increased ovarian follicle atresia in obese Zucker rats is associated with enhanced expression of the forkhead transcription factor FOXO1. Medical Molecular Morphology, Vol.42 (No.4). pp. 216-221. ISSN 1860-1480

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Abstract

It is well established that hyperinsulinemia, resulting from insulin resistance, plays a role in the pathophysiology of polycystic ovary syndrome (PCOS). The aim of this study was to investigate if ovarian follicular development and atresia are impaired in obese hyperinsulinemic (fa/fa) Zucker rats. To gain insight into the molecular mechanism of follicular atresia, we also examined the expression and localization of forkhead transcription factor FOXO1, a major regulator of cell fate decisions such as differentiation, cell-cycle arrest, and cell death. Serum insulin but not gonadotropin levels were significantly higher in obese (fa/fa) rats when compared to lean controls. Total ovarian follicle number and the percentage of atretic follicles were also significantly increased in obese (fa/fa) rats. Follicle atresia was associated with nuclear accumulation of FOXO1 transcription factor in TUNEL-positive granulosa cells. These results suggest a role for FOXO1 in granulosa cell apoptosis and increased ovarian follicle atresia associated with hyperinsulinemia.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology Q Science > QP Physiology
Divisions:	Faculty of Medicine > Warwick Medical School > Reproductive Health Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Apoptosis, Ovarian atresia, Zucker rats -- Physiology, Polycystic ovary syndrome -- Etiology -- Research, Transcription factors
Journal or Publication Title:	Medical Molecular Morphology
Publisher:	Springer Japan KK
ISSN:	1860-1480
Date:	December 2009
Volume:	Vol.42
Number:	No.4
Page Range:	pp. 216-221
Identification Number:	10.1007/s00795-009-0466-7
Status:	Peer Reviewed
Publication Status:	Published
Funder:	Japan. Monbu Kagakushō [Japan. Ministry of Education, Culture, Sports, Science and Technology] (MEXT)
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URI:	http://wrap.warwick.ac.uk/id/eprint/45894

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