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Inhibition of steroid sulfatase activity in endometriotic implants by STX64 (667Coumate) : a potential new therapy

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Fusi, L., Purohit, A., Brosens, Jan J., Woo, L. W. L., Potter, B. V. L. and Reed, M. J.. (2008) Inhibition of steroid sulfatase activity in endometriotic implants by STX64 (667Coumate) : a potential new therapy. Scientific World Journal, Vol.8 . pp. 1325-1327. ISSN 1537-744X

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Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Medicine > Warwick Medical School > Reproductive Health
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Endometriosis -- Treatment -- Research, Endometriosis -- Etiology -- Research, Sulfatases, Sulfatases -- Inhibitors
Journal or Publication Title: Scientific World Journal
Publisher: Scientific World Ltd.
ISSN: 1537-744X
Date: 2008
Volume: Vol.8
Page Range: pp. 1325-1327
Identification Number: 10.1100/tsw.2008.164
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
References: 1. Vigano, P., Parazzini, F., Somigliana, E., and Vercellini, P. (2004) Endometriosis: epidemiology and aetiological factors. Best Practice Res. Clin. Obstet. Gynaecol. 18, 177–200. 2. Sampson, J.A. (1927) Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity. Am. J. Obstet. Gynecol. 14, 422–425. 3. Nap, A., Groothuis, P.G., Demir, A.Y., Evers, J.L.H., and Dunselman, G.A.J. (2004) Pathogenesis of endometriosis. Best Practice Res. Clin. Obstet. Gynaecol. 18, 233–244. 4. Halme, I., White, C., Kauma, S., Estes, J., and Haskill, S. (1988) Peritoneal macrophages from patients with endometriosis release growth factor activity in vitro. J. Clin. Endocrinol. Metab. 66, 1044–1049. 5. Purohit, A., Fusi, L., Brosens, J., Woo, L.W.L., Potter, B.V.L., and Reed, M.J. (2008) Inhibition of steroid sulphatase activity in endometriotic implants by 667 COUMATE: a potential new therapy. Hum. Reprod. 23, 290–297. 6. Noble, L.S., Simpson, E.R., Johns, A., and Bulun, S.E. (1996) Aromatase expression in endometriosis. J. Clin. Endocrinol. Metab. 81, 174–179. 7. Noble, L.S., Takayama, K., Zeitoun, K.M., Putman, J.M., Johns, D.A., Hinselwood, M.M., Agarwal, V.R., Zhao, Y., Carr, B.R., and Bulun, S.E. (1997) Prostaglandin E2 stimulates aromatase expression in endometriosis derived stromal cells. J. Clin. Endocrinol. Metab. 82, 600–602. 8. Bulun, S.E., Zeitoun, K.M., Takayama, K., Simpson, E.R., and Sasano, H. (2000) Aromatase as a therapeutic agent in endometriosis. Trends Endocrinol. Metab. 11, 22–27. 9. Takayama, K., Zeitoun, K., Gunby, R.T., Sasano, H., Carr, B.R., and Bulun, S.E. (1998) Treatment of severe postmenopausal endometriosis with an aromatase inhibitor. Fertil. Steril. 69, 709–713. 10. Reed, M.J., Purohit, A., Woo, L.W.L., Newman, S.P., and Potter, B.V.L. (2005) Steroid sulphatase: molecular biology, regulation, and inhibition. Endocr. Rev. 26, 171–202. 11. Smuc, T., Pucely, M.R., Sinkovec, J., Husen, B., Thole, H., and Rizner, T.L. (2007) Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis. Gynecol. Endocrinol. 23, 105–111. 12. Zeitoun, K., Takayama, K., Sasano, H., Suzuki, T., Moghrabi, N., Anderson, S., Johns, A., Meng, L., Putman, M., Carr, B., et al. (1998) Deficient 17�-hydroxysteroid dehydrogenase Type 2 expression in endometriosis: failure to metabolize 17� estradiol. J. Clin. Endocrinol. Metab. 83, 4474–4480. 13. Purohit, A., Wang, D.Y., Ghilchik, M.W., and Reed, M.J. (1996) Regulation of aromatase and sulphatase in breast cancer cells. J. Endocrinol. 150(Suppl.), S56–S71. 14. Reed, M.J. and Purohit, A. (1997) Breast cancer and the role of cytokines in regulating estrogen synthesis: an emerging hypothesis. Endocr. Rev. 18, 701–715. 15. Woo, L.W.L., Purohit, A., Reed, M.J., and Potter, B.V.L. (1996) Active site-directed inhibition of estrone sulphatase by non-steroidal coumarin sulphamates. J. Med. Chem. 39, 1349–1351. 16. Woo, L.W.L., Purohit, A., Malini, B., Reed, M.J., and Potter, B.V.L. (2000) Potent active site-directed inhibitors of steroid sulphatase by tryciclic coumarin-base sulphamates. Chem. Biol. 7, 773–791. 17. Stanway, S.J., Purohit, A., Woo, L.W.L., et al. (2006) Phase I study of STX64 (667 COUMATE) in breast cancer patients: the first study of a steroid sulphatase inhibitor. Clin. Cancer Res. 12, 1585–1592. 18. (1985) Revised American Fertility Society classification for endometriosis. Fertil. Steril. 43, 351–352.
URI: http://wrap.warwick.ac.uk/id/eprint/45908

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