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Radiation-induced gut damage : identifying 'at risk' patients with an 'electronic nose' (E-NOSE)
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Arasaradnam, Ramesh P., Ouaret, N., Joseph, M., Nwokolo, Chuka U., Wedlake, L., Andreyev, J., Bardhan, Karna Dev and Covington, James A. (2011) Radiation-induced gut damage : identifying 'at risk' patients with an 'electronic nose' (E-NOSE). In: Digestive Disease Week (DDW) 2011, Chicago, U.S.A., May 7-10, 2011. Published in: Gastroenterology, Vol.140 (No.5 Suppl.1). S184-S185. doi:10.1136/gut.2011.239301.227 ISSN 0016-5085.
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Official URL: http://dx.doi.org/10.1136/gut.2011.239301.227
Abstract
Introduction Almost all patients undergoing radical pelvic radiotherapy develop bowel symptoms during treatment and half go on to develop chronic bowel symptoms. Acute histological damage, due to the radiation, is at its worst at 2 weeks and then improves; subsequent chronic damage then is sustained over many years. We investigated if changes in gastrointestinal symptoms during radiotherapy correlated with alterations in colonic microbial balance, reflected by changes in the gases released when undigested fibre is fermented.
Two hypotheses were investigated in this pilot study: (1) Irradiation alter the microbial flora, reflected by changes in the fermentation profile. (2) An individual's susceptibility to damage may be recognised by their ‘fermentation signature'.
| Item Type: | Conference Item (Paper) | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
| Journal or Publication Title: | Gastroenterology | ||||
| Publisher: | W.B. Saunders Co. | ||||
| ISSN: | 0016-5085 | ||||
| Official Date: | May 2011 | ||||
| Dates: |
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| Volume: | Vol.140 | ||||
| Number: | No.5 Suppl.1 | ||||
| Page Range: | S184-S185 | ||||
| DOI: | 10.1136/gut.2011.239301.227 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | Digestive Disease Week (DDW) 2011 | ||||
| Type of Event: | Conference | ||||
| Location of Event: | Chicago, U.S.A. | ||||
| Date(s) of Event: | May 7-10, 2011 |
Data sourced from Thomson Reuters' Web of Knowledge
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