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Low serum adiponectin predicts 10-year risk of type 2 diabetes and HbA1c independently of obesity, lipids, and inflammation : Whitehall II study
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Tabák, A. G., Brunner, E. J., Miller, Michelle A., Dr., Karanam, S., McTernan, P. G. (Philip G.), Cappuccio, Francesco P. and Witte, D. R.. (2009) Low serum adiponectin predicts 10-year risk of type 2 diabetes and HbA1c independently of obesity, lipids, and inflammation : Whitehall II study. Hormone and Metabolic Research, Vol.41 (No.8). pp. 626-629. ISSN 0018-5043
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Official URL: http://dx.doi.org/10.1055/s-0029-1216359
Abstract
Our aim of the present work was to study the effect of serum adiponectin on incident diabetes and HbA1c values. We measured baseline serum adiponectin levels in a nested case-control selection (n=140) of the Whitehall II Cohort. Participants (mean [SD] age 50.9 [6.3] years) had no prevalent diabetes or CHD at baseline. Cases (n=55) had incident diabetes according to an oral glucose tolerance test during follow-up (mean: 11.5±3.0 years). Adiponectin levels were lower among cases (9.3 μg/ml, 3.2 [median; IQR] vs. 10.5; 3.6, p=0.01). The risk of incident diabetes decreased by 11% (p=0.03) for 1 μg/ml higher adiponectin levels. Higher adiponectin levels were associated with lower HbA1c at follow-up (p<0.05). Both associations were stable to adjustment for age, sex, body mass index, systolic blood pressure, and serum lipids, and for the case of HbA1c, also for C-reactive protein (all p<0.05). The observed robust, prospective associations support that adiponectin is an independent predictor of diabetes and the degree of glycaemic impairment.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School |
| Journal or Publication Title: | Hormone and Metabolic Research |
| Publisher: | Georg Thieme Verlag |
| ISSN: | 0018-5043 |
| Date: | August 2009 |
| Volume: | Vol.41 |
| Number: | No.8 |
| Page Range: | pp. 626-629 |
| Identification Number: | 10.1055/s-0029-1216359 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/45952 |
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