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A mathematical model of cyclin B1 dynamics at the single cell level in osteosarcoma cells
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Pérez-Velázquez, J., Evans, Neil D., Chappell, M. J. (Michael J.), Errington, R, Smith, Paul J. and Khan, I. (2009) A mathematical model of cyclin B1 dynamics at the single cell level in osteosarcoma cells. In: 17th International Federation of Automatic Control World Congress (IFAC), Seoul, Republic of Korea, Jul 6-11, 2008. Published in: Proceedings of the 17th IFAC World Congress, 2008, Vol.17 (Part 1). pp. 9057-9062. doi:10.3182/20080706-5-KR-1001.01529 ISSN 1474-6670.
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Official URL: http://dx.doi.org/10.3182/20080706-5-KR-1001.01529
Abstract
Cyclin B1 tracking provides information on cell cycle progression and cell-cycle regulator dynamics. We have developed a mathematical model which describes the continuous tracking of cyclin B1 through the cell cycle at the single cell level, including interactions with the cyclin B1 inhibitor, p21. The cell line used is a cancer cell line, human osteosarcoma (U-2 OS). An examination of the sensitivity of the model is presented, where the aim is to identify those parameters which have most influence on the cyclin B1 profile and its changes through the cell cycle. High temporal resolution cyclin B1 data involving non-invasive techniques (green fluorescent protein, GFP) were used to validate the model.
| Item Type: | Conference Item (Paper) | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) T Technology > TA Engineering (General). Civil engineering (General) |
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| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
| Journal or Publication Title: | Proceedings of the 17th IFAC World Congress, 2008 | ||||
| Publisher: | International Federation of Automatic Control | ||||
| ISSN: | 1474-6670 | ||||
| Book Title: | Proceedings of the 17th IFAC World Congress, 2008 | ||||
| Official Date: | August 2009 | ||||
| Dates: |
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| Volume: | Vol.17 | ||||
| Number: | Part 1 | ||||
| Page Range: | pp. 9057-9062 | ||||
| DOI: | 10.3182/20080706-5-KR-1001.01529 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | 17th International Federation of Automatic Control World Congress (IFAC) | ||||
| Type of Event: | Conference | ||||
| Location of Event: | Seoul, Republic of Korea | ||||
| Date(s) of Event: | Jul 6-11, 2008 |
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