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Nonparametric prediction of free-light chain generation in multiple myeloma patients
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Hattersley, John G., Evans, Neil D., Chappell, M. J. (Michael J.), Mead, Graham P. and Hutchison, Colin A. (2009) Nonparametric prediction of free-light chain generation in multiple myeloma patients. In: 17th International Federation of Automatic Control World Congress (IFAC), Seoul, Republic of Korea, Jul 6-11, 2008. Published in: Proceedings of the 17th IFAC World Congress, 2008, Vol.17 (Part 1). pp. 8091-8096. doi:10.3182/20080706-5-KR-1001.01366 ISSN 1474-6670.
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Official URL: http://dx.doi.org/10.3182/20080706-5-KR-1001.01366
Abstract
Multiple Myeloma is a plasma cell cancer that produces excess Free Light Chains(FLC). Patients with this condition are treated with dialysis and chemotherapy. A previous compartmental model developed by Evans et al. [2006] described the removal of FLC through a hemodialysis membrane. In this model all rate constants were considered linear and the production of FLC a constant input function. It is known that the system rate constants and inputs are non-linear in nature due to the membrane dynamics and the use of chemotherapy to retard the production FLC producing cells. This study describes the use of maximum entropy deconvolution, in conjunction with a non-linear compartmental model, to recreate the FLC production rate in a non-parametric form, without the need for assumptions that are not supported by available data. Input functions are reconstructed from four different patients with a range of dialysis durations and FLC plasma concentrations to investigate the possible effects of chemotherapy on the underlying FLC production.
| Item Type: | Conference Item (Paper) | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) T Technology > TA Engineering (General). Civil engineering (General) |
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| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
| Journal or Publication Title: | Proceedings of the 17th IFAC World Congress, 2008 | ||||
| Publisher: | International Federation of Automatic Control | ||||
| ISSN: | 1474-6670 | ||||
| Book Title: | Proceedings of the 17th IFAC World Congress, 2008 | ||||
| Official Date: | August 2009 | ||||
| Dates: |
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| Volume: | Vol.17 | ||||
| Number: | Part 1 | ||||
| Page Range: | pp. 8091-8096 | ||||
| DOI: | 10.3182/20080706-5-KR-1001.01366 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | 17th International Federation of Automatic Control World Congress (IFAC) | ||||
| Type of Event: | Conference | ||||
| Location of Event: | Seoul, Republic of Korea | ||||
| Date(s) of Event: | Jul 6-11, 2008 |
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