Hattersley, J. G. (John G.), Evans, N. D., Chappell, M. J. (Michael J.), Mead, Graham P. and Hutchison, Colin A. (2009) Nonparametric prediction of free-light chain generation in multiple myeloma patients. In: 17th International Federation of Automatic Control World Congress (IFAC), Seoul, Republic of Korea, Jul 6-11, 2008. Published in: Proceedings of the 17th IFAC World Congress, 2008, Vol.17 (Part 1). pp. 8091-8096.

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Abstract

Multiple Myeloma is a plasma cell cancer that produces excess Free Light Chains(FLC). Patients with this condition are treated with dialysis and chemotherapy. A previous compartmental model developed by Evans et al. [2006] described the removal of FLC through a hemodialysis membrane. In this model all rate constants were considered linear and the production of FLC a constant input function. It is known that the system rate constants and inputs are non-linear in nature due to the membrane dynamics and the use of chemotherapy to retard the production FLC producing cells. This study describes the use of maximum entropy deconvolution, in conjunction with a non-linear compartmental model, to recreate the FLC production rate in a non-parametric form, without the need for assumptions that are not supported by available data. Input functions are reconstructed from four different patients with a range of dialysis durations and FLC plasma concentrations to investigate the possible effects of chemotherapy on the underlying FLC production.

Item Type:	Conference Item (Paper)
Subjects:	R Medicine > R Medicine (General) T Technology > TA Engineering (General). Civil engineering (General)
Divisions:	Faculty of Science > Engineering
Journal or Publication Title:	Proceedings of the 17th IFAC World Congress, 2008
Publisher:	International Federation of Automatic Control
ISSN:	1474-6670
Book Title:	Proceedings of the 17th IFAC World Congress, 2008
Date:	August 2009
Volume:	Vol.17
Number:	Part 1
Page Range:	pp. 8091-8096
Identification Number:	10.3182/20080706-5-KR-1001.01366
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Conference Paper Type:	Paper
Title of Event:	17th International Federation of Automatic Control World Congress (IFAC)
Type of Event:	Conference
Location of Event:	Seoul, Republic of Korea
Date(s) of Event:	Jul 6-11, 2008
URI:	http://wrap.warwick.ac.uk/id/eprint/45966

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