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Facile stoichiometric reductions in flow : an example of artemisinin
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Fan, Xiaolei, Sans, Victor, Yaseneva, Polina, Plaza, Dorota, Williams, Jonathan P. and Lapkin, Alexei (2012) Facile stoichiometric reductions in flow : an example of artemisinin. Organic Process Research & Development, Vol.16 (No.5). pp. 1039-1042. doi:10.1021/op200373m ISSN 1083-6160.
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Official URL: http://dx.doi.org/10.1021/op200373m
Abstract
Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h–1 L–1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.
Item Type: | Journal Article | ||||
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Subjects: | T Technology > TA Engineering (General). Civil engineering (General) T Technology > TP Chemical technology |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
Journal or Publication Title: | Organic Process Research & Development | ||||
Publisher: | American Chemical Society | ||||
ISSN: | 1083-6160 | ||||
Official Date: | 18 May 2012 | ||||
Dates: |
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Volume: | Vol.16 | ||||
Number: | No.5 | ||||
Number of Pages: | 4 | ||||
Page Range: | pp. 1039-1042 | ||||
DOI: | 10.1021/op200373m | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), University of Warwick | ||||
Grant number: | EP/F023456, EP/G028141 (EPSRC) |
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