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Facile stoichiometric reductions in flow: an example of artemisinin
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Fan, Xiaolei, Sans, Victor, Yaseneva, Polina, Plaza, Dorota D., Williams, Jonathan P. and Lapkin, Alexei. (2012) Facile stoichiometric reductions in flow: an example of artemisinin. Organic Process Research & Development, Vol.16 (No.5). pp. 1039-1042. ISSN 1083-6160
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Official URL: http://dx.doi.org/10.1021/op200373m
Abstract
Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h–1 L–1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.
| Item Type: | Journal Article |
|---|---|
| Subjects: | T Technology > TA Engineering (General). Civil engineering (General) T Technology > TP Chemical technology |
| Divisions: | Faculty of Science > Engineering |
| Journal or Publication Title: | Organic Process Research & Development |
| Publisher: | American Chemical Society |
| ISSN: | 1083-6160 |
| Date: | 18 May 2012 |
| Volume: | Vol.16 |
| Number: | No.5 |
| Number of Pages: | 4 |
| Page Range: | pp. 1039-1042 |
| Identification Number: | 10.1021/op200373m |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), University of Warwick |
| Grant number: | EP/F023456, EP/G028141 (EPSRC) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/45971 |
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