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Random and site-specific replication termination
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Dalgaard, Jacob Z., Eydmann, Trevor, Koulintchenko, Milana, Sayrac, Suha, Vengrova, Sonya and Yamada-Inagawa, Tomoko (2009) Random and site-specific replication termination. In: Vengrova, Sonya and Dalgaard, Jacob Z., (eds.) DNA replication : methods and protocols. Methods in molecular biology, Vol.521 . New York: Humana Press, pp. 35-53. ISBN 9781603278140
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Official URL: http://dx.doi.org/10.1007/978-1-60327-815-7_3
Abstract
Bi-directionality is a common feature observed for genomic replication for all three phylogenetic kingdoms: Eubacteria, Archaea, and Eukaryotes. A consequence of bi-directional replication, where the two replication forks initiated at an origin move away from each other, is that the replication termination will occur at positions away from the origin sequence(s). The replication termination processes are therefore physically and mechanistically dissociated from the replication initiation. The replication machinery is a highly processive complex that in short time copies huge numbers of bases while competing for the DNA substrate with histones, transcription factors, and other DNA-binding proteins. Importantly, the replication machinery generally wins out; meanwhile, when converging forks meet termination occurs, thus preventing over-replication and genetic instability. Very different scenarios for the replication termination processes have been described for the three phylogenetic kingdoms. In eubacterial genomes replication termination is site specific, while in archaea and eukaryotes termination is thought to occur randomly within zones where converging replication forks meet. However, a few site-specific replication barrier elements that mediate replication termination have been described in eukaryotes. This review gives an overview about what is known about replication termination, with a focus on these natural site-specific replication termination sites.
Item Type: | Book Item | ||||
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Subjects: | R Medicine > R Medicine (General) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Series Name: | Methods in molecular biology | ||||
Journal or Publication Title: | Methods in molecular biology (Clifton, N.J.) | ||||
Publisher: | Humana Press | ||||
Place of Publication: | New York | ||||
ISBN: | 9781603278140 | ||||
ISSN: | 1064-3745 | ||||
Book Title: | DNA replication : methods and protocols | ||||
Editor: | Vengrova, Sonya and Dalgaard, Jacob Z. | ||||
Official Date: | 2009 | ||||
Dates: |
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Volume: | Vol.521 | ||||
Number of Pages: | 0 | ||||
Page Range: | pp. 35-53 | ||||
DOI: | 10.1007/978-1-60327-815-7_3 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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