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Non-genomic progesterone actions in female reproduction
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Gellersen, B., Fernandes, M.S. and Brosens, Jan J. (2009) Non-genomic progesterone actions in female reproduction. Human Reproduction Update, Vol.15 (No.1). pp. 119-138. doi:10.1093/humupd/dmn044 ISSN 1355-4786.
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Official URL: http://dx.doi.org/10.1093/humupd/dmn044
Abstract
BACKGROUND The steroid hormone progesterone is indispensable for mammalian procreation by controlling key female reproductive events that range from ovulation to implantation, maintenance of pregnancy and breast development. In addition to activating the progesterone receptors (PRs)-B and -A, members of the superfamily of ligand-dependent transcription factors, progesterone also elicits a variety of rapid signalling events independently of transcriptional or genomic regulation. This review covers our current knowledge on the mechanisms and relevance of non-genomic progesterone signalling in female reproduction.
METHODS PubMed was searched up to August 2008 for papers on progesterone actions in ovary/breast/endometrium/myometrium/brain, focusing primarily on non-genomic signalling mechanisms.
RESULTS Convergence and intertwining of rapid non-genomic events and the slower transcriptional actions critically determine the functional response to progesterone in the female reproductive system in a cell-type- and environment-specific manner. Several putative progesterone-binding moieties have been implicated in rapid signalling events, including the ‘classical’ PR and its variants, progesterone receptor membrane component 1, and the novel family of membrane progestin receptors. Progesterone and its metabolites have also been implicated in the allosteric regulation of several unrelated receptors, such as γ-aminobutyric acid type A, oxytocin and sigma1 receptors.
CONCLUSIONS Identification of the mechanisms and receptors that relay rapid progesterone signalling is an area of research fraught with difficulties and controversy. More in-depth characterization of the putative receptors is required before the non-genomic progesterone pathway in normal and pathological reproductive function can be targeted for pharmacological intervention.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Human Reproduction Update | ||||
| Publisher: | Oxford University Press | ||||
| ISSN: | 1355-4786 | ||||
| Official Date: | January 2009 | ||||
| Dates: |
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| Volume: | Vol.15 | ||||
| Number: | No.1 | ||||
| Page Range: | pp. 119-138 | ||||
| DOI: | 10.1093/humupd/dmn044 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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