Tan, Bee K., Adya, Raghu and Randeva, Harpal S.. (2010) Omentin : a novel link between inflammation, diabesity, and cardiovascular disease. Trends in Cardiovascular Medicine, Vol.20 (No.5). pp. 143-148. ISSN 1050-1738

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Abstract

Obesity has reached pandemic proportions and is associated with serious cardiometabolic sequealae including insulin resistance, diabetes, dyslipidemia, hypertension, and cardiovascular disease, where adipose tissue–secreted cytokines, that is, adipokines, have been implicated in these processes. Omentin is a novel adipokine preferentially produced by visceral adipose tissue with insulin-sensitizing effects, where circulating levels are decreased in insulin-resistant states, for example, obesity and diabetes. With respect to vascular biology, omentin causes vasodilatation of blood vessels and attenuates C-reactive protein–induced angiogenesis potentially via the nuclear factor B signaling pathway, a potent proinflammatory signaling pathway. Thus, omentin may have beneficial effects on the metabolic syndrome and could potentially be used as a biologic marker and/or pharmacologic agent in this respect.

Item Type:	Journal Article
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Trends in Cardiovascular Medicine
Publisher:	Elsevier Inc.
ISSN:	1050-1738
Date:	July 2010
Volume:	Vol.20
Number:	No.5
Page Range:	pp. 143-148
Identification Number:	10.1016/j.tcm.2010.12.002
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/46136

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