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Cell-based surface acoustic wave resonant microsensor for biomolecular agent detection
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Racz, Z., Cole, Marina, Gardner, J. W., Pathak, S., Jordan, M. D. and Challiss, R. A. J. (2011) Cell-based surface acoustic wave resonant microsensor for biomolecular agent detection. In: The 16th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS 2011), Beijing, China, June 5-9, 2011. Published in: Proceedings of the 16th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS 2011) pp. 2168-2171. doi:10.1109/TRANSDUCERS.2011.5969348
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Official URL: http://dx.doi.org/10.1109/TRANSDUCERS.2011.5969348
Abstract
This paper describes the development of a novel surface acoustic wave (SAW)-based biosensor system for liquid phase biomolecular agent detection. The functional layer of the biosensor comprises Sf9 insect cells that can be efficiently used for the expression of specific ligand receptors and is coupled to the acousto-electric transducer. We introduce the dual bio-SAW sensor concept where only one side of a device pair is functionalized while the other side serves as a reference: enabling a differential output that obviates common mode variations. The detection of cellular responses to octopamine (an invertebrate neurotransmitter) was used to demonstrate the biosensor system's efficacy. We believe that this biological sensor system can be used more generally to monitor changes in cell biochemistry and physiology when subjected to different biomolecular agents, e.g. the detection of receptor-specific ligand binding.
| Item Type: | Conference Item (Paper) | ||||
|---|---|---|---|---|---|
| Subjects: | T Technology > TK Electrical engineering. Electronics Nuclear engineering | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
| Journal or Publication Title: | Proceedings of the 16th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS 2011) | ||||
| Publisher: | Institute of Electrical and Electronics Engineers | ||||
| Book Title: | 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference | ||||
| Official Date: | 2011 | ||||
| Dates: |
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| Page Range: | pp. 2168-2171 | ||||
| DOI: | 10.1109/TRANSDUCERS.2011.5969348 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | The 16th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS 2011) | ||||
| Type of Event: | Conference | ||||
| Location of Event: | Beijing, China | ||||
| Date(s) of Event: | June 5-9, 2011 |
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