Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems - role in ageing and disease
Thornalley, Paul J.. (2011) Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems - role in ageing and disease. Drug Metabolism and Drug Interactions, Vol.23 (No.1-2). pp. 125-150. ISSN 0792-5077Full text not available from this repository.
Official URL: http://dx.doi.org/10.1515/DMDI.2008.23.1-2.125
Glycation of proteins, nucleotides and basic phospholipids by glyoxal and methylglyoxal--physiological substrates of glyoxalase 1--is potentially damaging to the proteome, genome and lipidome. Glyoxalase 1 suppresses glycation by these alpha-oxoaldehyde metabolites and thereby represents part of the enzymatic defence against glycation. Albert Szent-Györgyi pioneered and struggled to understand the physiological function of methylglyoxal and the glyoxalase system. We now appreciate that glyoxalase 1 protects against dicarbonyl modifications of the proteome, genome and lipome. Latest research suggests there are functional modifications of this process--implying a role in cell signalling, ageing and disease.
|Item Type:||Journal Article|
|Subjects:||R Medicine > R Medicine (General)|
|Divisions:||Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Drug Metabolism and Drug Interactions|
|Publisher:||Walter de Gruyter GmbH & Co. KG|
|Page Range:||pp. 125-150|
|Access rights to Published version:||Restricted or Subscription Access|
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