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Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems - role in ageing and disease
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Thornalley, Paul J.. (2011) Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems - role in ageing and disease. Drug Metabolism and Drug Interactions, Vol.23 (No.1-2). pp. 125-150. ISSN 0792-5077
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Official URL: http://dx.doi.org/10.1515/DMDI.2008.23.1-2.125
Abstract
Glycation of proteins, nucleotides and basic phospholipids by glyoxal and methylglyoxal--physiological substrates of glyoxalase 1--is potentially damaging to the proteome, genome and lipidome. Glyoxalase 1 suppresses glycation by these alpha-oxoaldehyde metabolites and thereby represents part of the enzymatic defence against glycation. Albert Szent-Györgyi pioneered and struggled to understand the physiological function of methylglyoxal and the glyoxalase system. We now appreciate that glyoxalase 1 protects against dicarbonyl modifications of the proteome, genome and lipome. Latest research suggests there are functional modifications of this process--implying a role in cell signalling, ageing and disease.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School |
| Journal or Publication Title: | Drug Metabolism and Drug Interactions |
| Publisher: | Walter de Gruyter GmbH & Co. KG |
| ISSN: | 0792-5077 |
| Date: | May 2011 |
| Volume: | Vol.23 |
| Number: | No.1-2 |
| Page Range: | pp. 125-150 |
| Identification Number: | 10.1515/DMDI.2008.23.1-2.125 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/46287 |
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