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Modelling the double peak phenomenon in pharmacokinetics
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Godfrey, Keith R., Arundel, Philip A., Dong, Zimeng and Bryant, Robert (2009) Modelling the double peak phenomenon in pharmacokinetics. In: 7th IFAC Symposium on Modelling and Control in Biomedical Systems, Hvide Hus, Aalborg, Denmark, Aug 12-14, 2009. Published in: Modelling and Control in Biomedical Systems, Vol.7 (No.1). pp. 127-132. ISSN 0742-5953. doi:10.3182/20090812-3-DK-2006.00022
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Official URL: http://dx.doi.org/10.3182/20090812-3-DK-2006.00022
Abstract
Two approaches to describing the Double Peak Phenomenon in pharmacokinetics are compared. Both are based on compartmental modelling. The first assumes variability of absorption of the drug from the gut to the systemic plasma, with negligible absorption through the jejunum. This has the advantage of clear physiological interpretation, but the model has a comparatively large number of parameters to be estimated. The second approach assumes simultaneous input via two parallel pathways. This has considerably fewer parameters to be estimated, but it lacks the direct relationship to physiology. Almost equally good fits have been obtained from the two approaches when fitting to two data sets provided by AstraZeneca and to a data set from the literature.
| Item Type: | Conference Item (Paper) | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) T Technology > TA Engineering (General). Civil engineering (General) |
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| Divisions: | Faculty of Science > Engineering | ||||
| Journal or Publication Title: | Modelling and Control in Biomedical Systems | ||||
| Publisher: | The International Federation of Automatic Control | ||||
| ISSN: | 0742-5953 | ||||
| Book Title: | 7th IFAC Symposium on Modelling and Control in Biomedical Systems | ||||
| Official Date: | 2009 | ||||
| Dates: |
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| Volume: | Vol.7 | ||||
| Number: | No.1 | ||||
| Page Range: | pp. 127-132 | ||||
| DOI: | 10.3182/20090812-3-DK-2006.00022 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | 7th IFAC Symposium on Modelling and Control in Biomedical Systems | ||||
| Type of Event: | Other | ||||
| Location of Event: | Hvide Hus, Aalborg, Denmark | ||||
| Date(s) of Event: | Aug 12-14, 2009 |
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