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Modelling the double peak phenomenon in pharmacokinetics

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Godfrey, Keith R., Arundel, Philip A., Dong, Zimeng and Bryant, Robert (2009) Modelling the double peak phenomenon in pharmacokinetics. In: 7th IFAC Symposium on Modelling and Control in Biomedical Systems, Hvide Hus, Aalborg, Denmark, Aug 12-14, 2009. Published in: Modelling and Control in Biomedical Systems, Vol.7 (No.1). pp. 127-132. doi:10.3182/20090812-3-DK-2006.00022 ISSN 0742-5953.

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Official URL: http://dx.doi.org/10.3182/20090812-3-DK-2006.00022

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Abstract

Two approaches to describing the Double Peak Phenomenon in pharmacokinetics are compared. Both are based on compartmental modelling. The first assumes variability of absorption of the drug from the gut to the systemic plasma, with negligible absorption through the jejunum. This has the advantage of clear physiological interpretation, but the model has a comparatively large number of parameters to be estimated. The second approach assumes simultaneous input via two parallel pathways. This has considerably fewer parameters to be estimated, but it lacks the direct relationship to physiology. Almost equally good fits have been obtained from the two approaches when fitting to two data sets provided by AstraZeneca and to a data set from the literature.

Item Type: Conference Item (Paper)
Subjects: R Medicine > R Medicine (General)
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Science, Engineering and Medicine > Engineering > Engineering
Journal or Publication Title: Modelling and Control in Biomedical Systems
Publisher: The International Federation of Automatic Control
ISSN: 0742-5953
Book Title: 7th IFAC Symposium on Modelling and Control in Biomedical Systems
Official Date: 2009
Dates:
DateEvent
2009Published
Volume: Vol.7
Number: No.1
Page Range: pp. 127-132
DOI: 10.3182/20090812-3-DK-2006.00022
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Conference Paper Type: Paper
Title of Event: 7th IFAC Symposium on Modelling and Control in Biomedical Systems
Type of Event: Other
Location of Event: Hvide Hus, Aalborg, Denmark
Date(s) of Event: Aug 12-14, 2009

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