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Silica-gelatin hybrids with tailorable degradation and mechanical properties for tissue regeneration
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Mahony, Oliver, Tsigkou, Olga, Ionescu, Claudia, Minelli, Caterina, Ling, Lowell, Hanly, Ruth, Smith, Mark E., Stevens, Molly M. and Jones, Julian R. (2010) Silica-gelatin hybrids with tailorable degradation and mechanical properties for tissue regeneration. Advanced Functional Materials, Vol.20 (No.22). pp. 3835-3845. doi:10.1002/adfm.201000838 ISSN 1616-301X.
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Official URL: http://dx.doi.org/10.1002/adfm.201000838
Abstract
Nature has evolved mechanisms to create a diversity of specialized materials through nanoscale organization. Inspired by nature, hybrid materials are designed with highly tailorable properties, which are achieved through careful control of their nanoscale interactions. These novel materials, based on a silica-gelatin hybrid system, have the potential to serve as a platform technology for human tissue regeneration. Covalent interactions between the inorganic and organic constituents of the hybrid are essential to enable the precise control of mechanical and dissolution properties. Furthermore, hybrid scaffold porosity is found to highly influence mechanical properties, to the extent where scaffolds of particular strength could be specified based on their porosity. The hybrids also demonstrate a non-cytotoxic effect when mesenchymal stem cells are cultured on the material. Cytoskeletal proteins of the cells are imaged using actin and vimentin staining. It is envisaged these hybrid materials will find a diverse application in both hard and soft tissue regenerating scaffolds.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry T Technology T Technology > TA Engineering (General). Civil engineering (General) Q Science > QC Physics |
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| Divisions: | Administration > University Executive Office Faculty of Science, Engineering and Medicine > Science > Physics |
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| Journal or Publication Title: | Advanced Functional Materials | ||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||
| ISSN: | 1616-301X | ||||
| Official Date: | 23 November 2010 | ||||
| Dates: |
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| Volume: | Vol.20 | ||||
| Number: | No.22 | ||||
| Number of Pages: | 11 | ||||
| Page Range: | pp. 3835-3845 | ||||
| DOI: | 10.1002/adfm.201000838 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), University of Warwick, European Regional Development Fund (ERDF), Regional Development Agency (AWM) | ||||
| Grant number: | EP/E057098 (EPSRC), EP/E051669 (EPSRC) |
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