Mahony, Oliver, Tsigkou, Olga, Ionescu, Claudia, Minelli, Caterina, Ling, Lowell, Hanly, Ruth, Smith, Mark E., Stevens, Molly M. and Jones, Julian R.. (2010) Silica-gelatin hybrids with tailorable degradation and mechanical properties for tissue regeneration. Advanced Functional Materials, Vol.20 (No.22). pp. 3835-3845. ISSN 1616-301X

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Abstract

Nature has evolved mechanisms to create a diversity of specialized materials through nanoscale organization. Inspired by nature, hybrid materials are designed with highly tailorable properties, which are achieved through careful control of their nanoscale interactions. These novel materials, based on a silica-gelatin hybrid system, have the potential to serve as a platform technology for human tissue regeneration. Covalent interactions between the inorganic and organic constituents of the hybrid are essential to enable the precise control of mechanical and dissolution properties. Furthermore, hybrid scaffold porosity is found to highly influence mechanical properties, to the extent where scaffolds of particular strength could be specified based on their porosity. The hybrids also demonstrate a non-cytotoxic effect when mesenchymal stem cells are cultured on the material. Cytoskeletal proteins of the cells are imaged using actin and vimentin staining. It is envisaged these hybrid materials will find a diverse application in both hard and soft tissue regenerating scaffolds.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry T Technology T Technology > TA Engineering (General). Civil engineering (General) Q Science > QC Physics
Divisions:	Administration > Vice Chancellor's Office Faculty of Science > Physics
Journal or Publication Title:	Advanced Functional Materials
Publisher:	Wiley - V C H Verlag GmbH & Co. KGaA
ISSN:	1616-301X
Date:	23 November 2010
Volume:	Vol.20
Number:	No.22
Number of Pages:	11
Page Range:	pp. 3835-3845
Identification Number:	10.1002/adfm.201000838
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC), University of Warwick, European Regional Development Fund (ERDF), Regional Development Agency (AWM)
Grant number:	EP/E057098 (EPSRC), EP/E051669 (EPSRC)
URI:	http://wrap.warwick.ac.uk/id/eprint/4636

Data sourced from Thomson Reuters' Web of Knowledge

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