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Purines as potential morphogens during embryonic development
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Masse, Karine and Dale, Nicholas (2012) Purines as potential morphogens during embryonic development. Purinergic Signalling, Vol.8 (No.3). pp. 503-521. doi:10.1007/s11302-012-9290-y ISSN 1573-9538.
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Official URL: http://dx.doi.org/10.1007/s11302-012-9290-y
Abstract
Components of purinergic signalling are expressed
in the early embryo raising the possibility that ATP, ADP and adenosine may contribute to the mechanisms of embryonic development. We summarize the available data from four developmental models—mouse, chick, Xenopus and zebrafish. While there are some notable examples where purinergic signalling is indeed important during development, e.g. development of the eye in the frog, it is puzzling that deletion of single components of purinergic signalling often results in rather minor developmental phenotypes. We suggest that a key step in further analysis is to perform combinatorial alterations
of expression of purinergic signalling components to
uncover their roles in development.We introduce the concept that purinergic signalling could create novel morphogenetic fields to encode spatial location via the concentration of ATP, ADP and adenosine. We show that using minimal assumptions and the known properties of the ectonucleotidases, complex spatial patterns of ATP and adenosine can be set up. These patterns may provide a new way to assess the potential of purinergic signalling in developmental processes.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QL Zoology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Library of Congress Subject Headings (LCSH): | Embryology, Purines | ||||
Journal or Publication Title: | Purinergic Signalling | ||||
Publisher: | Springer | ||||
ISSN: | 1573-9538 | ||||
Official Date: | September 2012 | ||||
Dates: |
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Volume: | Vol.8 | ||||
Number: | No.3 | ||||
Page Range: | pp. 503-521 | ||||
DOI: | 10.1007/s11302-012-9290-y | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 21 December 2015 | ||||
Date of first compliant Open Access: | 21 December 2015 |
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