Kaverina, Irina and Straube, Anne. (2011) Regulation of cell migration by dynamic microtubules. Seminars in Cell & Developmental Biology, Volume 22 (Number 9). pp. 968-974. ISSN 1084-9521

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Abstract

Microtubules define the architecture and internal organization of cells by positioning organelles and activities, as well as by supporting cell shape and mechanics. One of the major functions of microtubules is the control of polarized cell motility. In order to support the asymmetry of polarized cells, microtubules have to be organized asymmetrically themselves. Asymmetry in microtubule distribution and stability is regulated by multiple molecular factors, most of which are microtubule-associated proteins that locally control microtubule nucleation and dynamics. At the same time, the dynamic state of microtubules is key to the regulatory mechanisms by which microtubules regulate cell polarity, modulate cell adhesion and control force-production by the actin cytoskeleton. Here, we propose that even small alterations in microtubule dynamics can influence cell migration via several different microtubule-dependent pathways. We discuss regulatory factors, potential feedback mechanisms due to functional microtubule-actin crosstalk and implications for cancer cell motility.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology Q Science > QR Microbiology
Divisions:	Faculty of Medicine > Warwick Medical School > Biomedical Cell Biology Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Microtubules, Cell organelles, Cell migration, Cytology, Cells -- Motility, Microbiology -- Research , Cancer cells -- Motility
Journal or Publication Title:	Seminars in Cell & Developmental Biology
Publisher:	Elsevier Ltd
ISSN:	1084-9521
Date:	December 2011
Volume:	Volume 22
Number:	Number 9
Page Range:	pp. 968-974
Identification Number:	10.1016/j.semcdb.2011.09.017
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	National Institutes of Health (U.S.) (NIH), National Institute of General Medical Sciences (U.S.) (NIGMS), American Heart Association (AHA), Marie Curie Cancer Care, University of Warwick
Grant number:	R01 GM078373 (NIH NIGMS) ; 10GRNT4230026
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URI:	http://wrap.warwick.ac.uk/id/eprint/46397

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