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Regulation of cell migration by dynamic microtubules
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Kaverina, Irina and Straube, Anne (2011) Regulation of cell migration by dynamic microtubules. Seminars in Cell & Developmental Biology, Volume 22 (Number 9). pp. 968-974. doi:10.1016/j.semcdb.2011.09.017 ISSN 1084-9521.
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Official URL: http://dx.doi.org/10.1016/j.semcdb.2011.09.017
Abstract
Microtubules define the architecture and internal organization of cells by positioning organelles and activities, as well as by supporting cell shape and mechanics. One of the major functions of microtubules is the control of polarized cell motility. In order to support the asymmetry of polarized cells, microtubules have to be organized asymmetrically themselves. Asymmetry in microtubule distribution and stability is regulated by multiple molecular factors, most of which are microtubule-associated proteins that locally control microtubule nucleation and dynamics. At the same time, the dynamic state of microtubules is key to the regulatory mechanisms by which microtubules regulate cell polarity, modulate cell adhesion and control force-production by the actin cytoskeleton. Here, we propose that even small alterations in microtubule dynamics can influence cell migration via several different microtubule-dependent pathways. We discuss regulatory factors, potential feedback mechanisms due to functional microtubule-actin crosstalk and implications for cancer cell motility.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QR Microbiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Microtubules, Cell organelles, Cell migration, Cytology, Cells -- Motility, Microbiology -- Research , Cancer cells -- Motility | ||||
| Journal or Publication Title: | Seminars in Cell & Developmental Biology | ||||
| Publisher: | Elsevier Ltd | ||||
| ISSN: | 1084-9521 | ||||
| Official Date: | December 2011 | ||||
| Dates: |
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| Volume: | Volume 22 | ||||
| Number: | Number 9 | ||||
| Page Range: | pp. 968-974 | ||||
| DOI: | 10.1016/j.semcdb.2011.09.017 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Date of first compliant deposit: | 21 December 2015 | ||||
| Date of first compliant Open Access: | 21 December 2015 | ||||
| Funder: | National Institutes of Health (U.S.) (NIH), National Institute of General Medical Sciences (U.S.) (NIGMS), American Heart Association (AHA), Marie Curie Cancer Care, University of Warwick | ||||
| Grant number: | R01 GM078373 (NIH NIGMS) ; 10GRNT4230026 |
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