Myatt, Stephen S., Brosens, Jan J. and Lam, Eric W.-F.. (2011) Sense and sensitivity : FOXO and ROS in cancer development and treatment. Antioxidants & Redox Signaling, Vol.14 (No.4). pp. 675-687. ISSN 1523-0864

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Abstract

Forkhead box O (FOXO) transcription factors are at the center of an emerging paradigm that links longevity, cell fate, and tumor development. Key to these processes is the ability of FOXO to regulate, and be regulated by, oxidative stress. Perturbation of the mechanisms that tightly couple reactive oxygen species (ROS) production, oxidative stress signaling, and FOXO activity to the subsequent cellular response is a pivotal step in cancer development and progression. Consequently, the ROS-FOXO pathway is a major therapeutic target in cancer, not only as it mediates the cellular response to chemotherapy, but also because it underpins drug resistance. As the intimate and reciprocal relation between FOXO and ROS is being unravelled, new opportunities arise to develop more-effective cancer treatments that circumvent resistance to the conventional cytotoxic drugs. Antioxid. Redox Signal. 14, 675—687.

Item Type:	Journal Article
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Reproductive Health Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Antioxidants & Redox Signaling
Publisher:	Mary Ann Liebert, Inc. Publishers
ISSN:	1523-0864
Official Date:	15 February 2011
Dates:	Date Event 15 February 2011 Published
Volume:	Vol.14
Number:	No.4
Page Range:	pp. 675-687
Identification Number:	10.1089/ars.2010.3383
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/46459

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