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Sense and sensitivity : FOXO and ROS in cancer development and treatment
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Myatt, Stephen S., Brosens, Jan J. and Lam, Eric W.-F. (2011) Sense and sensitivity : FOXO and ROS in cancer development and treatment. Antioxidants & Redox Signaling, Vol.14 (No.4). pp. 675-687. doi:10.1089/ars.2010.3383 ISSN 1523-0864.
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Official URL: http://dx.doi.org/10.1089/ars.2010.3383
Abstract
Forkhead box O (FOXO) transcription factors are at the center of an emerging paradigm that links longevity, cell fate, and tumor development. Key to these processes is the ability of FOXO to regulate, and be regulated by, oxidative stress. Perturbation of the mechanisms that tightly couple reactive oxygen species (ROS) production, oxidative stress signaling, and FOXO activity to the subsequent cellular response is a pivotal step in cancer development and progression. Consequently, the ROS-FOXO pathway is a major therapeutic target in cancer, not only as it mediates the cellular response to chemotherapy, but also because it underpins drug resistance. As the intimate and reciprocal relation between FOXO and ROS is being unravelled, new opportunities arise to develop more-effective cancer treatments that circumvent resistance to the conventional cytotoxic drugs. Antioxid. Redox Signal. 14, 675—687.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Antioxidants & Redox Signaling | ||||
| Publisher: | Mary Ann Liebert, Inc. Publishers | ||||
| ISSN: | 1523-0864 | ||||
| Official Date: | 15 February 2011 | ||||
| Dates: |
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| Volume: | Vol.14 | ||||
| Number: | No.4 | ||||
| Page Range: | pp. 675-687 | ||||
| DOI: | 10.1089/ars.2010.3383 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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