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Severe thiamine deficiency complicated by weight loss protects against renal ischaemia-reperfusion injury in rats
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Klooster, A., Larkin, J. R., Adaikalakoteswari, A., Gans, R. O. B., van Goor, H., Thornalley, Paul J., Rabbani, N., Navis, G., Leuvenink, H. G. D. and Bakker, S. J. L. (2009) Severe thiamine deficiency complicated by weight loss protects against renal ischaemia-reperfusion injury in rats. NDT Plus, Vol.2 (No.2). pp. 182-183. ISSN 1753-0784
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Official URL: http://dx.doi.org/10.1093/ndtplus/sfn194
Abstract
Injury due to reperfusion after prior ischaemia (IRI) is an important cause of delayed graft function after renal transplantation [1]. Studies in dogs and rats suggest that thiamine is protective against IRI in heart and brain [2–4]. It has been argued that many organs, including kidneys are deficient in thiamine at the moment of transplantation [4]. We aimed to investigate the effect of severe tissue thiamine deficiency on ischaemia-reperfusion injury in rat kidneys.
| Item Type: | Journal Item |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School |
| Journal or Publication Title: | NDT Plus |
| Publisher: | Oxford University Press |
| ISSN: | 1753-0784 |
| Date: | April 2009 |
| Volume: | Vol.2 |
| Number: | No.2 |
| Page Range: | pp. 182-183 |
| Identification Number: | 10.1093/ndtplus/sfn194 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/46468 |
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