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Simon's minimax and optimal and Jung's admissible two-stage designs with or without curtailment

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Kunz, Cornelia and Kieser, M. (2011) Simon's minimax and optimal and Jung's admissible two-stage designs with or without curtailment. Stata Journal, Vol.11 (No.2). pp. 240-254.

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Abstract

This article describes a new Stata command called simontwostage, which calculates the critical values and sample sizes for two-stage designs for phase II oncology trials. Options are provided to determine the minimax and optimal designs proposed by Simon (1989, Controlled Clinical Trials 10: 1–10) and admissible designs described by Jung et al. (2004, Statistics in Medicine 23: 561–569). Furthermore, nonstochastic and stochastic curtailment rules can be implemented in both stages of the trial, and the properties of the curtailed designs can be examined.

Item Type: Journal Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Stata Journal
Publisher: Stata Press
ISSN: 1536-867X
Official Date: 2011
Dates:
DateEvent
2011Published
Volume: Vol.11
Number: No.2
Page Range: pp. 240-254
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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