The Library
The CCAN complex : linking centromere specification to control of kinetochore–microtubule dynamics
Tools
McAinsh, Andrew D. and Meraldi, Patrick (2011) The CCAN complex : linking centromere specification to control of kinetochore–microtubule dynamics. Seminars in Cell & Developmental Biology, Vol.22 (No.9). pp. 946-952. doi:10.1016/j.semcdb.2011.09.016 ISSN 1084-9521.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.semcdb.2011.09.016
Abstract
For over 70 years, chromosomes have been known to oscillate back-and-forth on the metaphase plate. These movements are directed by kinetochores, the microtubule-attachment complexes on centromeres that regulate the dynamics of bound spindle microtubules. Recent evidence shows that the CCAN (Constitutive Centromere Associated Network) kinetochore network, which directly binds centromeric nucleosomes, plays a crucial role in the control of kinetochore microtubule dynamics. Here we review how this 15-subunit protein network functions within the kinetochore machinery, how it may adapt dynamically both in time and in space to the functional requirements necessary for controlled and faithful chromosome movements during cell division, and how this conserved protein network may have evolved in organisms with different cell division machineries.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | R Medicine > R Medicine (General) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||
Journal or Publication Title: | Seminars in Cell & Developmental Biology | ||||
Publisher: | Elsevier Ltd | ||||
ISSN: | 1084-9521 | ||||
Official Date: | December 2011 | ||||
Dates: |
|
||||
Volume: | Vol.22 | ||||
Number: | No.9 | ||||
Page Range: | pp. 946-952 | ||||
DOI: | 10.1016/j.semcdb.2011.09.016 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Swiss National Research Fund, Swiss Cancer League, European Research Council (ERC), Marie Curie Cancer Care |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |