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Charge transport in cancer-related genes and early carcinogenesis
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Shih, Chi-Tin, Cheng, Yun-Yin, Wells, Stephen A., Hsu, Ching-Ling and Römer, Rudolf A. (2011) Charge transport in cancer-related genes and early carcinogenesis. Computer Physics Communications, Vol.182 (No.1). pp. 36-38. doi:10.1016/j.cpc.2010.06.029 ISSN 0010-4655.
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Official URL: http://dx.doi.org/10.1016/j.cpc.2010.06.029
Abstract
The electronic transmission properties of DNA molecules are believed to play a significant role in many physical phenomena taking place in living organisms (Chakraborty 2007) [1] Here we study the charge transport (CT) properties of cancer-related genes including some of the most important tumor suppressors We find that the changes in averaged CT around the sites of pathogenic and cancerous mutations are statistically smaller than those on sites where pathogenic mutations have not been observed The results suggest that CT might be an indicator to discriminate between pathogenic and non-pathogenic mutations at an early stage Mutations which cause little change in CT may be more likely to occur or more likely to be missed by damage-repair enzymes which probe CT and are therefore more likely to persist and cause disease Crown Copyright (C) 2010 Published by Elsevier BV All rights reserved
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QC Physics Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||
| Library of Congress Subject Headings (LCSH): | DNA, Charge transfer, Cancer genes, Mutation (Biology), Carcinogenesis | ||||
| Journal or Publication Title: | Computer Physics Communications | ||||
| Publisher: | Elsevier Science BV | ||||
| ISSN: | 0010-4655 | ||||
| Official Date: | January 2011 | ||||
| Dates: |
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| Volume: | Vol.182 | ||||
| Number: | No.1 | ||||
| Number of Pages: | 3 | ||||
| Page Range: | pp. 36-38 | ||||
| DOI: | 10.1016/j.cpc.2010.06.029 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Leverhulme Trust (LT), National Science Council of Taiwan (NSCTW), National Center for High-Performance Computing (Taiwan) (NCHC) | ||||
| Grant number: | 97-2112-M-029-002-MY3 (NSCTW), F/00215/AH (LT) |
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