Shih, Chi-Tin, Cheng, Yun-Yin, Wells, Stephen A., Hsu, Ching-Ling and Roemer, Rudolf A.. (2011) Charge transport in cancer-related genes and early carcinogenesis. Computer Physics Communications, Vol.182 (No.1). pp. 36-38. ISSN 0010-4655

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Abstract

The electronic transmission properties of DNA molecules are believed to play a significant role in many physical phenomena taking place in living organisms (Chakraborty 2007) [1] Here we study the charge transport (CT) properties of cancer-related genes including some of the most important tumor suppressors We find that the changes in averaged CT around the sites of pathogenic and cancerous mutations are statistically smaller than those on sites where pathogenic mutations have not been observed The results suggest that CT might be an indicator to discriminate between pathogenic and non-pathogenic mutations at an early stage Mutations which cause little change in CT may be more likely to occur or more likely to be missed by damage-repair enzymes which probe CT and are therefore more likely to persist and cause disease Crown Copyright (C) 2010 Published by Elsevier BV All rights reserved

Item Type:	Journal Article
Subjects:	Q Science > QC Physics Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions:	Faculty of Science > Physics
Library of Congress Subject Headings (LCSH):	DNA, Charge transfer, Cancer genes, Mutation (Biology), Carcinogenesis
Journal or Publication Title:	Computer Physics Communications
Publisher:	Elsevier Science BV
ISSN:	0010-4655
Date:	January 2011
Volume:	Vol.182
Number:	No.1
Number of Pages:	3
Page Range:	pp. 36-38
Identification Number:	10.1016/j.cpc.2010.06.029
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Leverhulme Trust (LT), National Science Council of Taiwan (NSCTW), National Center for High-Performance Computing (Taiwan) (NCHC)
Grant number:	97-2112-M-029-002-MY3 (NSCTW), F/00215/AH (LT)
References:	[1] T. Chakraborty (Ed.), Charge Migration in DNA: Perspectives from Physics, Chemistry and Biology, Springer Verlag, Berlin, 2007. [2] C.J. Sherr, Cell 116 (2004) 235. [3] S.R. Rajski, B.A. Jackson, J.K. Barton, Mutat. Res. 447 (2000) 49. [4] C.-T. Shih, S. Roche, R.A. Römer, Phys. Rev. Lett. 100 (2008) 018105. [5] P.D. Steson, et al., Hum. Mutat. 21 (2003) 577, http://www.hgmd.cf.ac.uk/ ac/index.php. [6] A. Petitjean, et al., Hum. Mutat. 28 (622) (2007) R11, http://www-p53.iarc. fr/index.html. [7] S.A. Wells, C.-T. Shih, R.A. Römer, Int. J. Mod. Phys. B (2009) 4138. [8] S. Roche, Phys. Rev. Lett. 91 (2003) 108101. [9] M.L. Ndawana, R.A. Römer, M. Schreiber, Europhys. Lett. 68 (2004) 678. [10] C.-T. Shih, Y.-Y. Cheng, S.A. Wells, C.-L. Hsu, R.A. Römer, unpublished (2010).
URI:	http://wrap.warwick.ac.uk/id/eprint/4653

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