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The diversity of sex steroid action : the role of micro-RNAs and FOXO transcription factors in cycling endometrium and cancer
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Lam, E. W.-F., Shah, K. and Brosens, Jan J.. (2012) The diversity of sex steroid action : the role of micro-RNAs and FOXO transcription factors in cycling endometrium and cancer. Journal of Endocrinology, Vol.212 (No.1). pp. 13-25. ISSN 0022-0795
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Official URL: http://dx.doi.org/10.1530/JOE-10-0480
Abstract
The rise and fall in ovarian estrogen and progesterone production orchestrates a series of events that are indispensable for reproduction, including ovulation, implantation, decidualisation and menstruation. In the uterus, these events involve extensive tissue remodelling, characterised by waves of endometrial cell proliferation, differentiation, recruitment of inflammatory cells, apoptosis, tissue breakdown, menstruation and regeneration. The ability of ovarian hormones to trigger such diverse physiological responses is foremost dependent upon interaction of activated steroid receptors with specific transcription factors, such FOXO proteins, involved in cell fate decisions. Furthermore, microRNAs, small non-coding RNAs that function as posttranscriptional regulators of gene expression, have emerged as a major regulator system of steroid hormone responses in the female reproductive tract. Consequently, increasing evidence shows that deregulated uterine microRNA expression underpins a spectrum of common reproductive disorders, ranging from implantation failure to endometriosis. Furthermore, by targeting FOXO transcription factors and other key regulators of tissue homeostasis, oncogenic endometrial microRNAs promote tumorigenesis and cancer progression.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Warwick Medical School > Reproductive Health Faculty of Medicine > Warwick Medical School |
| Journal or Publication Title: | Journal of Endocrinology |
| Publisher: | Society for Endocrinology |
| ISSN: | 0022-0795 |
| Date: | 7 March 2012 |
| Volume: | Vol.212 |
| Number: | No.1 |
| Page Range: | pp. 13-25 |
| Identification Number: | 10.1530/JOE-10-0480 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/46546 |
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