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Still entangled : assembly of the central spindle by multiple microtubule modulators

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Douglas, Max E. and Mishima, Masanori. (2010) Still entangled : assembly of the central spindle by multiple microtubule modulators. Seminars in Cell & Developmental Biology, Vol.21 (No.9). pp. 899-908. ISSN 1084-9521

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Official URL: http://dx.doi.org/10.1016/j.semcdb.2010.08.005

Abstract

The central spindle is a microtubule-based structure that assembles during anaphase of mitosis in animal cells and is essential for multiple steps of cytokinesis. Central spindle assembly occurs by the cooperative action of multiple microtubule motors and modulators. Here, we review the mechanism by which the central spindle is formed, the role of several key proteins in this process and how central spindle assembly is temporally and spatially coordinated with mitosis.

Item Type: Journal Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Cell Biology
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Seminars in Cell & Developmental Biology
Publisher: Elsevier Ltd
ISSN: 1084-9521
Date: December 2010
Volume: Vol.21
Number: No.9
Page Range: pp. 899-908
Identification Number: 10.1016/j.semcdb.2010.08.005
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
URI: http://wrap.warwick.ac.uk/id/eprint/46616

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