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Still entangled : assembly of the central spindle by multiple microtubule modulators
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Douglas, Max E. and Mishima, Masanori (2010) Still entangled : assembly of the central spindle by multiple microtubule modulators. Seminars in Cell & Developmental Biology, Vol.21 (No.9). pp. 899-908. doi:10.1016/j.semcdb.2010.08.005 ISSN 1084-9521.
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Official URL: http://dx.doi.org/10.1016/j.semcdb.2010.08.005
Abstract
The central spindle is a microtubule-based structure that assembles during anaphase of mitosis in animal cells and is essential for multiple steps of cytokinesis. Central spindle assembly occurs by the cooperative action of multiple microtubule motors and modulators. Here, we review the mechanism by which the central spindle is formed, the role of several key proteins in this process and how central spindle assembly is temporally and spatially coordinated with mitosis.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Seminars in Cell & Developmental Biology | ||||
| Publisher: | Elsevier Ltd | ||||
| ISSN: | 1084-9521 | ||||
| Official Date: | December 2010 | ||||
| Dates: |
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| Volume: | Vol.21 | ||||
| Number: | No.9 | ||||
| Page Range: | pp. 899-908 | ||||
| DOI: | 10.1016/j.semcdb.2010.08.005 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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