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Still entangled : assembly of the central spindle by multiple microtubule modulators

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Douglas, Max E. and Mishima, Masanori (2010) Still entangled : assembly of the central spindle by multiple microtubule modulators. Seminars in Cell & Developmental Biology, Vol.21 (No.9). pp. 899-908. doi:10.1016/j.semcdb.2010.08.005

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Official URL: http://dx.doi.org/10.1016/j.semcdb.2010.08.005

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Abstract

The central spindle is a microtubule-based structure that assembles during anaphase of mitosis in animal cells and is essential for multiple steps of cytokinesis. Central spindle assembly occurs by the cooperative action of multiple microtubule motors and modulators. Here, we review the mechanism by which the central spindle is formed, the role of several key proteins in this process and how central spindle assembly is temporally and spatially coordinated with mitosis.

Item Type: Journal Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Seminars in Cell & Developmental Biology
Publisher: Elsevier Ltd
ISSN: 1084-9521
Official Date: December 2010
Dates:
DateEvent
December 2010Published
Volume: Vol.21
Number: No.9
Page Range: pp. 899-908
DOI: 10.1016/j.semcdb.2010.08.005
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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