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Photo-induced pyridine substitution in cis-[Ru(bpy)(2)(py)(2)]Cl-2 : a snapshot by time-resolved X-ray solution scattering

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Salassa, Luca, Borfecchia, Elisa, Ruiu, Tiziana, Garino, Claudio, Gianolio, Diego, Gobetto, Roberto, Sadler, P. J., Cammarata, Marco, Wulff, Michael and Lamberti, Carlo. (2010) Photo-induced pyridine substitution in cis-[Ru(bpy)(2)(py)(2)]Cl-2 : a snapshot by time-resolved X-ray solution scattering. Inorganic Chemistry, Vol.49 (No.23). pp. 11240-11248. ISSN 0020-1669

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Official URL: http://dx.doi.org/10.1021/ic102021k

Abstract

Determination of transient structures in light-induced processes is a challenging goal for time-resolved techniques. Such techniques are becoming successful in detecting ultrafast structural changes in molecules and do not require the presence of probe-like groups. Here, we demonstrate that TR-WAXS (Time-Resolved Wide Angle X-ray Scattering) can be successfully employed to study the photochemistry of cis-[Ru(bpy)(2)(py)(2)]Cl-2, a mononuclear ruthenium complex of interest in the field of photoactivatable anticancer agents. TR-WAXS is able to detect the release of a pyridine ligand and the coordination of a solvent molecule on a faster timescale than 800 ns of laser excitation. The direct measurement of the photodissociation of pyridine is a major advance in the field of time-resolved techniques allowing detection, for the first time, of the release of a multiatomic ligand formed by low Z atoms. These data demonstrate that TR-WAXS is a powerful technique for studying rapid ligand substitution processes involving photoactive metal complexes of biological interest.

Item Type:	Journal Article
Subjects:	Q Science > QC Physics Q Science > QD Chemistry Q Science > QP Physiology
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	X-rays -- Scattering, Pyridine, Substitution reactions, Time-resolved spectroscopy, Photochemistry, Antineoplastic agents, Ruthenium
Journal or Publication Title:	Inorganic Chemistry
Publisher:	American Chemical Society
ISSN:	0020-1669
Date:	6 December 2010
Volume:	Vol.49
Number:	No.23
Number of Pages:	9
Page Range:	pp. 11240-11248
Identification Number:	10.1021/ic102021k
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Seventh Framework Programme (European Commission) (FP7), European Research Council (ERC)
Grant number:	247450 (ERC), 220281 (FP7)
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URI:	http://wrap.warwick.ac.uk/id/eprint/4680