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ITIH-5 Expression in human adipose tissue is increased in obesity
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Anveden, Åsa, Sjoholm, Kajsa, Jacobson, Peter, Palsdottir, Vilborg, Walley, Andrew, Froguel, Philippe, Al-Daghri, Nasser M., McTernan, P. G. (Philip G.), Mejhert, Niklas, Arner, Peter, Sjostrom, Lars, Carlsson, Lena M. S. and Svensson, Per-Arne (2012) ITIH-5 Expression in human adipose tissue is increased in obesity. Obesity, Vol.20 (No.4). pp. 708-714. doi:10.1038/oby.2011.268 ISSN 1930-7381.
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Official URL: http://dx.doi.org/10.1038/oby.2011.268
Abstract
Adipocytes secrete many proteins that regulate metabolic functions. The gene inter-α (globulin) inhibitor H5 (ITIH-5) encodes a secreted protein and is known to be expressed abundantly in the placenta. However, using gene expression profiles data we observed high expression of ITIH-5 in adipose tissue. The aim of this study was to test the hypothesis that ITIH-5 is strongly expressed in human adipocytes and adipose tissue, and is related to obesity and clinical metabolic variables. ITIH-5 adipose tissue mRNA expression was analyzed with DNA microarray and real-time PCR, and its association with clinical variables was examined. ITIH-5 protein expression was analyzed using western blot. ITIH-5 mRNA expression was abundant in human adipose tissue, adipocytes, and placenta, and higher in subcutaneous (sc) compared to omental adipose tissue (P < 0.0001). ITIH-5 mRNA and protein expression in sc adipose tissue were higher in obese compared to lean subjects (P < 0.0001 and P < 0.001, respectively). ITIH-5 mRNA expression was reduced after diet-induced weight loss (P < 0.0001). ITIH-5 mRNA expression was associated with anthropometry and clinical metabolic variables. In conclusion, ITIH-5 is highly expressed in sc adipose tissue, increased in obesity, down regulated after weight loss, and associated with measures of body size and metabolism. Together, this indicates that ITIH-5 merits further investigation as a regulator of human metabolism.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Obesity | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 1930-7381 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | Vol.20 | ||||
Number: | No.4 | ||||
Page Range: | pp. 708-714 | ||||
DOI: | 10.1038/oby.2011.268 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published |
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