. (2010) Signatures of adaptation to obligate biotrophy in the hyaloperonospora arabidopsidis genome. Science, Vol.330 (No.6010). pp. 1549-1551. ISSN 0036-8075

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Abstract

Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy.

Item Type:	Journal Article
Subjects:	Q Science
Divisions:	Faculty of Science > Life Sciences (2010- )
Journal or Publication Title:	Science
Publisher:	American Association for the Advancement of Science
ISSN:	0036-8075
Date:	10 December 2010
Volume:	Vol.330
Number:	No.6010
Number of Pages:	3
Page Range:	pp. 1549-1551
Identification Number:	10.1126/science.1195203
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), National Science Foundation (U.S.) (NSF), U.S. Department of Agriculture National Institute of Food and Agriculture, Gatsby
Grant number:	EF-0412213, IOS-0744875, IOS-0924861, MCB-0639226, 2004-35600-15055, 2007-35319-18100, BB/C509123/1, BB/E024815/1, BB/F0161901, T12144, EP/F500025/1, GAT2545
URI:	http://wrap.warwick.ac.uk/id/eprint/4705

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