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Signatures of adaptation to obligate biotrophy in the hyaloperonospora arabidopsidis genome
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(2010) Signatures of adaptation to obligate biotrophy in the hyaloperonospora arabidopsidis genome. Science, Vol.330 (No.6010). pp. 1549-1551. doi:10.1126/science.1195203 Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1126/science.1195203
Abstract
Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
| Journal or Publication Title: | Science | ||||
| Publisher: | American Association for the Advancement of Science | ||||
| ISSN: | 0036-8075 | ||||
| Official Date: | 10 December 2010 | ||||
| Dates: |
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| Volume: | Vol.330 | ||||
| Number: | No.6010 | ||||
| Number of Pages: | 3 | ||||
| Page Range: | pp. 1549-1551 | ||||
| DOI: | 10.1126/science.1195203 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), National Science Foundation (U.S.) (NSF), U.S. Department of Agriculture National Institute of Food and Agriculture, Gatsby | ||||
| Grant number: | EF-0412213, IOS-0744875, IOS-0924861, MCB-0639226, 2004-35600-15055, 2007-35319-18100, BB/C509123/1, BB/E024815/1, BB/F0161901, T12144, EP/F500025/1, GAT2545 |
Data sourced from Thomson Reuters' Web of Knowledge
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