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Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia — link to renal status, glycemic control and vascular inflammation
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Antonysunil, Adaikalakoteswari, Rabbani, Naila, Waspadji, Sarwono, Tjokroprawiro, Askandar, Kariadi, Sri H.K.S., Adam, John M.F. and Thornalley, Paul J. (2012) Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia — link to renal status, glycemic control and vascular inflammation. Diabetes Research and Clinical Practice, Vol.95 (No.3). pp. 415-424. doi:10.1016/j.diabres.2011.10.042 ISSN 0168-8227.
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Official URL: http://dx.doi.org/10.1016/j.diabres.2011.10.042
Abstract
Background
Diabetes is associated with mishandling of thiamine in the kidney and development of diabetic nephropathy. The aim of this study is to assess the disturbance of thiamine and other B-vitamin status of patients with type 2 diabetes in Indonesia.
Methods
One hundred and fifteen patients with type 2 diabetes with and without microalbuminuria or albuminuria and 39 healthy people were recruited. After a 2-month washout period for B-vitamin supplementation, markers of vitamins B1, B6, B9 and B12, were determined.
Results
Fractional excretion of thiamine (22.8 versus 33.5%; P<0.05) and urinary excretion of the vitamin B6 degradation product 4-pyridoxic acid (0.081 versus 0.133μmol/g creatinine, P<0.001) was increased in patients with type 2 diabetes with respect to healthy controls. There was also increased total plasma cobalamin (398 versus 547pmol/l, P<0.001) and holotranscobalamin (74 versus 97pmol/l, P<0.001) in patients with type 2 diabetes. In multiple regression analysis these were linked to HbA1c, duration of diabetes and systolic blood pressure, and fasting plasma glucose, folate and C-reactive protein, respectively.
Conclusions
There was renal mishandling of thiamine, increased degradation of vitamin B6 and cytosolic metabolic resistance to vitamin B12 in patients with type 2 diabetes in Indonesia.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Diabetes Research and Clinical Practice | ||||
| Publisher: | Elsevier Ireland Ltd | ||||
| ISSN: | 0168-8227 | ||||
| Official Date: | March 2012 | ||||
| Dates: |
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| Volume: | Vol.95 | ||||
| Number: | No.3 | ||||
| Page Range: | pp. 415-424 | ||||
| DOI: | 10.1016/j.diabres.2011.10.042 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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