Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia — link to renal status, glycemic control and vascular inflammation
Adaikalakoteswari, Antonysunil, Rabbani, Naila, Waspadji, Sarwono, Tjokroprawiro, Askandar, Kariadi, Sri H.K.S., Adam, John M.F. and Thornalley, Paul J.. (2012) Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia — link to renal status, glycemic control and vascular inflammation. Diabetes Research and Clinical Practice, Vol.95 (No.3). pp. 415-424. ISSN 0168-8227Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.diabres.2011.10.042
Diabetes is associated with mishandling of thiamine in the kidney and development of diabetic nephropathy. The aim of this study is to assess the disturbance of thiamine and other B-vitamin status of patients with type 2 diabetes in Indonesia.
One hundred and fifteen patients with type 2 diabetes with and without microalbuminuria or albuminuria and 39 healthy people were recruited. After a 2-month washout period for B-vitamin supplementation, markers of vitamins B1, B6, B9 and B12, were determined.
Fractional excretion of thiamine (22.8 versus 33.5%; P<0.05) and urinary excretion of the vitamin B6 degradation product 4-pyridoxic acid (0.081 versus 0.133μmol/g creatinine, P<0.001) was increased in patients with type 2 diabetes with respect to healthy controls. There was also increased total plasma cobalamin (398 versus 547pmol/l, P<0.001) and holotranscobalamin (74 versus 97pmol/l, P<0.001) in patients with type 2 diabetes. In multiple regression analysis these were linked to HbA1c, duration of diabetes and systolic blood pressure, and fasting plasma glucose, folate and C-reactive protein, respectively.
There was renal mishandling of thiamine, increased degradation of vitamin B6 and cytosolic metabolic resistance to vitamin B12 in patients with type 2 diabetes in Indonesia.
|Item Type:||Journal Article|
|Subjects:||R Medicine > R Medicine (General)|
|Divisions:||Faculty of Medicine > Warwick Medical School|
|Journal or Publication Title:||Diabetes Research and Clinical Practice|
|Publisher:||Elsevier Ireland Ltd|
|Official Date:||March 2012|
|Page Range:||pp. 415-424|
|Access rights to Published version:||Restricted or Subscription Access|
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