Broyd, Samantha J., Demanuele, C., Debener, S., Helps, Suzannah K., James, C. J. and Sonuga-Barke, E. J. S.. (2009) Default-mode brain dysfunction in mental disorders: A systematic review. Neuroscience & Biobehavioral Reviews, Vol.33 (No.3). pp. 279-296. ISSN 0149-7634

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Abstract

In this review we are concerned specifically with the putative role of the default-mode network (DMN) in the pathophysiology of mental disorders. First, we define the DMN concept with regard to its neuro-anatomy, its functional organisation through low frequency neuronal oscillations, its relation to other recently discovered low frequency resting state networks, and the cognitive functions it is thought to serve. Second, we introduce methodological and analytical issues and challenges. Third, we describe putative mechanisms proposed to link DMN abnormalities and mental disorders. These include interference by network activity during task performance, altered patterns of antagonism between task specific and non-specific elements, altered connectively and integrity of the DMN, and altered psychological functions served by the network DMN. Fourth, we review the empirical literature systematically. We relate DMN dysfunction to dementia, schizophrenia, epilepsy, anxiety and depression, autism and attention deficit/hyperactivity disorder drawing out common and unique elements of the disorders. Finally, we provide an integrative overview and highlight important challenges and tasks for future research.

Item Type:	Journal Article
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Science > WMG (Formerly the Warwick Manufacturing Group)
Journal or Publication Title:	Neuroscience & Biobehavioral Reviews
Publisher:	Pergamon
ISSN:	0149-7634
Official Date:	March 2009
Volume:	Vol.33
Number:	No.3
Number of Pages:	17
Page Range:	pp. 279-296
Identification Number:	10.1016/j.neubiorev.2008.09.002
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/47139

Data sourced from Thomson Reuters' Web of Knowledge

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