James, C. J. and Gupta, D. (2009) Seizure prediction for epilepsy using a multi-stage phase synchrony based system. In: Annual Conference of the IEEE Engineering in Medicine and Biology Society 2009, Minneapolis, MN, U.S.A., Sep 3-6, 2009. Published in: Proceedings of the Annual Conference of the IEEE Engineering in Medicine and Biology Society 2009 pp. 25-28. ISSN 1557-170X, ISBN:978-1-4244-3296-7. doi:10.1109/IEMBS.2009.5334898

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Abstract

Seizure onset prediction in epilepsy is a challenge which is under investigation using many and varied signal processing techniques. Here we present a multi-stage phase synchrony based system that brings to bear the advantages of many techniques in each substage. The 1st stage of the system unmixes continuous long-term (2-4 days) multichannel scalp EEG using spatially constrained Independent Component Analysis and estimates the long term significant phase synchrony dynamics of narrowband (2-8 Hz and 8-14 Hz) seizure components. It then projects multidimensional features onto a 2-D map using Neuroscale and evaluates the probability of predictive events using Gaussian Mixture Models. We show the possibility of seizure onset prediction within a prediction window of 35-65 minutes with a sensitivity of 65-100% and specificity of 65-80% across epileptic patients.

Item Type:	Conference Item (Paper)
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions:	Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group)
Journal or Publication Title:	Proceedings of the Annual Conference of the IEEE Engineering in Medicine and Biology Society 2009
Publisher:	Institute of Electrical and Electronics Engineers
ISSN:	1557-170X, ISBN:978-1-4244-3296-7
Book Title:	2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Official Date:	2009
Dates:	Date Event 2009 Published
Page Range:	pp. 25-28
DOI:	10.1109/IEMBS.2009.5334898
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Conference Paper Type:	Paper
Title of Event:	Annual Conference of the IEEE Engineering in Medicine and Biology Society 2009
Type of Event:	Conference
Location of Event:	Minneapolis, MN, U.S.A.
Date(s) of Event:	Sep 3-6, 2009

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