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Seizure prediction for epilepsy using a multi-stage phase synchrony based system
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James, C. J. and Gupta, D. (2009) Seizure prediction for epilepsy using a multi-stage phase synchrony based system. In: Annual Conference of the IEEE Engineering in Medicine and Biology Society 2009, Minneapolis, MN, U.S.A., Sep 3-6, 2009. Published in: Proceedings of the Annual Conference of the IEEE Engineering in Medicine and Biology Society 2009 pp. 25-28. ISSN 1557-170X, ISBN:978-1-4244-3296-7. doi:10.1109/IEMBS.2009.5334898
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Official URL: http://dx.doi.org/10.1109/IEMBS.2009.5334898
Abstract
Seizure onset prediction in epilepsy is a challenge which is under investigation using many and varied signal processing techniques. Here we present a multi-stage phase synchrony based system that brings to bear the advantages of many techniques in each substage. The 1st stage of the system unmixes continuous long-term (2-4 days) multichannel scalp EEG using spatially constrained Independent Component Analysis and estimates the long term significant phase synchrony dynamics of narrowband (2-8 Hz and 8-14 Hz) seizure components. It then projects multidimensional features onto a 2-D map using Neuroscale and evaluates the probability of predictive events using Gaussian Mixture Models. We show the possibility of seizure onset prediction within a prediction window of 35-65 minutes with a sensitivity of 65-100% and specificity of 65-80% across epileptic patients.
| Item Type: | Conference Item (Paper) | ||||
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| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry T Technology > TK Electrical engineering. Electronics Nuclear engineering |
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| Divisions: | Faculty of Science > WMG (Formerly the Warwick Manufacturing Group) | ||||
| Journal or Publication Title: | Proceedings of the Annual Conference of the IEEE Engineering in Medicine and Biology Society 2009 | ||||
| Publisher: | Institute of Electrical and Electronics Engineers | ||||
| ISSN: | 1557-170X, ISBN:978-1-4244-3296-7 | ||||
| Book Title: | 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society | ||||
| Official Date: | 2009 | ||||
| Dates: |
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| Page Range: | pp. 25-28 | ||||
| DOI: | 10.1109/IEMBS.2009.5334898 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | Annual Conference of the IEEE Engineering in Medicine and Biology Society 2009 | ||||
| Type of Event: | Conference | ||||
| Location of Event: | Minneapolis, MN, U.S.A. | ||||
| Date(s) of Event: | Sep 3-6, 2009 |
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