Demanuele, C., James, C. J., Capilla, A. and Sonuga-Barke, E. J. S. (2009) Extracting event-related field components through space-time ICA: a study of MEG recordings from children with ADHD and controls. In: 4th European Conference Of The International Federation For Medical And Biological Engineering, Antwerp, Belgium, Nov 23-27, 2008. Published in: IFMBE Proceedings, Vol.22 pp. 38-42.

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Abstract

Event-related studies have provided indirect evidence that Attention Deficit Hyperactivity Disorder (ADHD) children have abnormalities in signal detection and discrimination, and in information processing. Moreover, studies suggest that there exist very low frequency fluctuations modulating underlying neuronal events. This paper presents an event-related fields (ERF) study involving the analysis of magnetoencephalographic (MEG) recordings of children with ADHD and controls during selective attention and perceptual, stimuli-based tasks. A specific form of blind-source separation — space-time independent component analysis (ST-ICA) — is used to isolate the early M100 responses within the data, which are indicative of selective attention deficits. The properties of the extracted responses, namely the amplitude and latency, as well as the power spectral densities of their inter-trial variations are then analyzed. Preliminary results demonstrate the ability of ST-ICA to extract relevant components from multi-dimensional, noisy, ERF data, and reveal differences in the amplitude and latency variations of the M100 responses of the two groups.

Item Type:	Conference Item (Paper)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions:	Faculty of Science > WMG (Formerly the Warwick Manufacturing Group)
Journal or Publication Title:	IFMBE Proceedings
Publisher:	International Federation for Medical and Biological Engineering
ISSN:	1680-0737
Book Title:	4th European Conference of the International Federation for Medical and Biological Engineering
Volume:	Vol.22
Page Range:	pp. 38-42
Identification Number:	10.1007/978-3-540-89208-3_11
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Conference Paper Type:	Paper
Title of Event:	4th European Conference Of The International Federation For Medical And Biological Engineering
Type of Event:	Conference
Location of Event:	Antwerp, Belgium
Date(s) of Event:	Nov 23-27, 2008
URI:	http://wrap.warwick.ac.uk/id/eprint/47167

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