The Library

Tools for metal ion sorting : in vitro evidence for partitioning of zinc and cadmium in C. elegans metallothionein isoforms

Tools

Leszczyszyn, Oksana I., Zeitoun-Ghandour, Sukaina, Stuerzenbaum, Stephen R. and Blindauer, Claudia A.. (2011) Tools for metal ion sorting : in vitro evidence for partitioning of zinc and cadmium in C. elegans metallothionein isoforms. Chemical Communications, Vol.47 (No.1). pp. 448-450. ISSN 1359-7345

Full text not available from this repository.

Official URL: http://dx.doi.org/10.1039/c0cc02188a

Abstract

In vitro evidence for the isoform-specific partitioning of cadmium and zinc ions between the two C. elegans metallothioneins is presented. This observation is discussed in terms of isoform-specific affinities towards zinc and cadmium and the implications of our study on the in vivo roles of C. elegans metallothioneins.

Item Type:

Journal Article

Subjects:

Q Science > QD Chemistry
Q Science > QP Physiology

Divisions:

Faculty of Science > Chemistry

Library of Congress Subject Headings (LCSH):

Metallothionein, Metal ions, Homeostasis, Zinc, Cadmium, Electrospray ionization mass spectrometry

Journal or Publication Title:

Chemical Communications

Publisher:

Royal Society of Chemistry

ISSN:

1359-7345

Official Date:

2011

Dates:

Date	Event
2011	Published

Volume:

Vol.47

Number:

No.1

Number of Pages:

Page Range:

pp. 448-450

Identification Number:

10.1039/c0cc02188a

Status:

Peer Reviewed

Publication Status:

Published

Access rights to Published version:

Restricted or Subscription Access

Funder:

Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Altajir Trust, Advantage West Midlands (AWM), European Regional Development Fund (ERDF)

Grant number:

BBE025099 (BBSRC)

References:

1 (a) Y. Chen, R. S. Simmonds, G. L. Sloan and R. Timkovich,
J. Biol. Inorg. Chem., 2008, 13, 855–860; (b) C. A. Blindauer,
M. D. Harrison, J. A. Parkinson, N. J. Robinson and P. J. Sadler,
in 10th Int. Symp. on Metal Ions in Biology and Medicine, ed.
P. Collery, I. Maymard, T. Theophanides, L. Khassanova and
T. Collery, John Libby Eurotext, 2008, vol. 10, pp. 167–173.
2 (a) O. I. Leszczyszyn and C. A. Blindauer, Mol. BioSyst., 2010, 6,
1592–1603; (b) P. Palumaa, O. Njunkova, L. Pokras, E. Eriste,
H. Jo¨ rnvall and R. Sillard, FEBS Lett., 2002, 527, 76–80.
3 R. Kothinti, A. Blodgett, N. M. Tabatabai and D. H. Petering,
Chem. Res. Toxicol., 2010, 23, 405–412.
4 F. Thevenod, Toxicol. Appl. Pharmacol., 2009, 238, 221–239.
5 M. l. Viaua, J. Gastaldo, Z. Bencokova, A. Joubert and N. Foray,
Mutat. Res., 2008, 365, 13–21.
6 N. M. Tabatabai, S. S. Blumenthal and D. H. Petering,
Toxicology, 2005, 207, 369–382.
7 K. Balamurugan and W. Schaffner, Met. Ions Life Sci., 2009, 5,
31–49.
8 M. Nordberg and G. F. Nordberg, Met. Ions Life Sci., 2009, 5,
1–29.
9 D. Egli, A. Selvaraj, H. Yepiskoposyan, B. Zhang, E. Hafen,
O. Georgiev and W. Schaffner, EMBO J., 2003, 22, 100–108.
10 R. Bofill, M. Capdevila and S. Atrian, Metallomics, 2009, 1,
229–234.
11 J. H. Freedman, L. W. Slice, D. Dixon, A. Fire and C. S. Rubin,
J. Biol. Chem., 1993, 268, 554–564.
12 S. C. Swain, K. Keusekotten, R. Baumeister and
S. R. Sturzenbaum, J. Mol. Biol., 2004, 341, 951–959.
13 S. Zeitoun-Ghandour, J. M. Charnock, M. E. Hodson,
O. I. Leszczyszyn, C. A. Blindauer and S. R. Stu¨ rzenbaum, FEBS
J., 2010, 277, 2531–2542.
14 P. Palumaa, I. Tammiste, K. Kruusel, L. Kangur, H. Jo¨ rnvall and
R. Sillard, Biochim. Biophys. Acta, Proteins Proteomics, 2005,
1747, 205–211.
15 R. Bofill, R. Orihuela, M. Romagosa, J. Domenech, S. Atrian and
M. Capdevila, FEBS J., 2009, 276, 7040–7069.
16 C. A. Blindauer, N. C. Polfer, S. E. Keiper, M. D. Harrison,
N. J. Robinson, P. R. R. Langridge-Smith and P. J. Sadler, J. Am.
Chem. Soc., 2003, 125, 3226–3227.
17 B. A. Krizek, D. L. Merkle and J. M. Berg, Inorg. Chem., 1993, 32,
937–940.
18 D. W. Hasler, L. T. Jensen, O. Zerbe, D. R. Winge and M. Vasak,
Biochemistry, 2000, 39, 14567–14575.