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Synthesis and characterization of gel casting and freeze casting derived porous bioceramic scaffolds
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Mallick, Kajal and Nithyanandan, Anouska (2011) Synthesis and characterization of gel casting and freeze casting derived porous bioceramic scaffolds. In: 113th Annual Meeting of the American Ceramic Society, Materials Science and Technology 2011 Conference and Exhibition, Columbus, OH, U.S.A., Oct 16-20, 2011
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Abstract
The development of highly controllable fabrication techniques is vital in producing implantable bone scaffolds suitable for clinical use. Bioresorbable HAp, Bioglass® and composite bioscaffolds have been successfully manufactured by freeze casting and gel casting. For porcine gelatin based gel casting methods, variation of HAp loading (10-60wt%) and gelatin concentration (1-6wt%) resulted in interconnected 3D scaffolds with macroporosity (50-2000μm) and microporosity (0.5-50μm). In contrast, freeze casting employed camphor and camphene as freezing vehicle to fabricate interconnected HAp scaffolds with some macropores. Camphor yielded largely micropores of 2-6μm compared to 1-5μm for camphene. Micropores and interconnectivity are thought to be beneficial to promote cell behaviour and healing critical bone defects. Camphor offered a wider temperature window for handling than camphene due to its higher T<SUB>m</SUB> with a higher degree of control in processing and development of microstructure. DTA-TG, SEM, XRD and μCT have been used to characterize the scaffolds and precursor materials.
Item Type: | Conference Item (Paper) | ||||
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Subjects: | R Medicine > R Medicine (General) T Technology > TA Engineering (General). Civil engineering (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) |
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Official Date: | 2011 | ||||
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Status: | Not Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Conference Paper Type: | Paper | ||||
Title of Event: | 113th Annual Meeting of the American Ceramic Society, Materials Science and Technology 2011 Conference and Exhibition | ||||
Type of Event: | Conference | ||||
Location of Event: | Columbus, OH, U.S.A. | ||||
Date(s) of Event: | Oct 16-20, 2011 |
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