Synthesis and characterization of gel casting and freeze casting derived porous bioceramic scaffolds
Mallick, Kajal, -2013 and Nithyanandan, Anouska (2011) Synthesis and characterization of gel casting and freeze casting derived porous bioceramic scaffolds. In: 113th Annual Meeting of the American Ceramic Society, Materials Science and Technology 2011 Conference and Exhibition, Columbus, OH, U.S.A., Oct 16-20, 2011Full text not available from this repository.
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The development of highly controllable fabrication techniques is vital in producing implantable bone scaffolds suitable for clinical use. Bioresorbable HAp, Bioglass® and composite bioscaffolds have been successfully manufactured by freeze casting and gel casting. For porcine gelatin based gel casting methods, variation of HAp loading (10-60wt%) and gelatin concentration (1-6wt%) resulted in interconnected 3D scaffolds with macroporosity (50-2000μm) and microporosity (0.5-50μm). In contrast, freeze casting employed camphor and camphene as freezing vehicle to fabricate interconnected HAp scaffolds with some macropores. Camphor yielded largely micropores of 2-6μm compared to 1-5μm for camphene. Micropores and interconnectivity are thought to be beneficial to promote cell behaviour and healing critical bone defects. Camphor offered a wider temperature window for handling than camphene due to its higher T<SUB>m</SUB> with a higher degree of control in processing and development of microstructure. DTA-TG, SEM, XRD and μCT have been used to characterize the scaffolds and precursor materials.
|Item Type:||Conference Item (Paper)|
|Subjects:||R Medicine > R Medicine (General)
T Technology > TA Engineering (General). Civil engineering (General)
|Divisions:||Faculty of Science > Engineering
Faculty of Science > WMG (Formerly the Warwick Manufacturing Group)
|Status:||Not Peer Reviewed|
|Access rights to Published version:||Open Access|
|Conference Paper Type:||Paper|
|Title of Event:||113th Annual Meeting of the American Ceramic Society, Materials Science and Technology 2011 Conference and Exhibition|
|Type of Event:||Conference|
|Location of Event:||Columbus, OH, U.S.A.|
|Date(s) of Event:||Oct 16-20, 2011|
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