Synthesis and characterization of gel casting and freeze casting derived porous bioceramic scaffolds
Mallick, Kajal K. and Nithyanandan, Anouska (2011) Synthesis and characterization of gel casting and freeze casting derived porous bioceramic scaffolds. In: 113th Annual Meeting of the American Ceramic Society, Materials Science and Technology 2011 Conference and Exhibition, Columbus, OH, U.S.A., Oct 16-20, 2011Full text not available from this repository.
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The development of highly controllable fabrication techniques is vital in producing implantable bone scaffolds suitable for clinical use. Bioresorbable HAp, Bioglass® and composite bioscaffolds have been successfully manufactured by freeze casting and gel casting. For porcine gelatin based gel casting methods, variation of HAp loading (10-60wt%) and gelatin concentration (1-6wt%) resulted in interconnected 3D scaffolds with macroporosity (50-2000μm) and microporosity (0.5-50μm). In contrast, freeze casting employed camphor and camphene as freezing vehicle to fabricate interconnected HAp scaffolds with some macropores. Camphor yielded largely micropores of 2-6μm compared to 1-5μm for camphene. Micropores and interconnectivity are thought to be beneficial to promote cell behaviour and healing critical bone defects. Camphor offered a wider temperature window for handling than camphene due to its higher T<SUB>m</SUB> with a higher degree of control in processing and development of microstructure. DTA-TG, SEM, XRD and μCT have been used to characterize the scaffolds and precursor materials.
|Item Type:||Conference Item (Paper)|
|Subjects:||R Medicine > R Medicine (General)
T Technology > TA Engineering (General). Civil engineering (General)
|Divisions:||Faculty of Science > Engineering
Faculty of Science > WMG (Formerly the Warwick Manufacturing Group)
|Status:||Not Peer Reviewed|
|Access rights to Published version:||Open Access|
|Conference Paper Type:||Paper|
|Title of Event:||113th Annual Meeting of the American Ceramic Society, Materials Science and Technology 2011 Conference and Exhibition|
|Type of Event:||Conference|
|Location of Event:||Columbus, OH, U.S.A.|
|Date(s) of Event:||Oct 16-20, 2011|
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