Johnson, T. D., Xu, Lei, Nichols, Thomas E. and Wager, T. (2009) Spatial point process modelling of group fMRI data analysis. In: ENAR Spring Meeting, San Antonio, TX, U.S.A., Mar 15-18, 2009. Published in: Final program of the 2009 ENAR Spring Meeting p. 56.

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Abstract

We propose a Bayesian hierarchical spatial model for multi-subject fMRI data. While there has been much work on univariate modeling of each voxel for single- and multi subject data, and some work on spatial modeling for single-subject data, there has been virtually no work on spatial models that explicitly account for inter-subject variability in activation location. Most previous models use Gaussian mixtures for the activation shape. At the first level, we use Gaussian mixtures for the probability that a voxel belongs to an activated region. Spatial correlation is accounted for in the mixing weights. At the second level, mixture component means are clustered about individual activation centers and a priori are assumed to arise from a Cox cluster process. At the third level, individual activation centers are clustered about population centers, again arising from a Cox cluster process. At the fourth level, population centers are a priori, modelled as a homogeneous Poisson process. Our approach incorporates the unknown number of mixture components and individual centers into the model as parameters whose posterior intensities are estimated by reversible jump Markov Chain Monte Carlo. We demonstrate our method on a recently published fMRI study.

Item Type:	Conference Item (Paper)
Subjects:	H Social Sciences > HA Statistics Q Science > QA Mathematics R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Science, Engineering and Medicine > Science > Statistics Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group)
Journal or Publication Title:	Final program of the 2009 ENAR Spring Meeting
Publisher:	International Biometric Society
Official Date:	March 2009
Dates:	Date Event March 2009 Published
Page Range:	p. 56
Status:	Not Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Conference Paper Type:	Paper
Title of Event:	ENAR Spring Meeting
Type of Event:	Conference
Location of Event:	San Antonio, TX, U.S.A.
Date(s) of Event:	Mar 15-18, 2009

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