Yap, Kevin Yi-Lwern, Low, Xiu Hui and Chan, Alexandre. (2011) Utilizing a pharmacoinformatics tool for the prediction of chemotherapy-induced nausea and vomiting in Asian patients on emetogenic chemotherapies. Supportive Care In Cancer, Vol.19 (Suppl.2). S110-S111. ISSN 0941-4355

Abstract

Objectives: A pharmacoinformatics tool was employed in this prospective, cohort study to determine its utility in identifying risk factors that are useful as predictors of chemotherapy-induced nausea and vomiting (CINV). Methods: Asian patients on a variety of chemotherapy regimens and appropriate antiemetic treatment were recruited from January 2007–July 2010. CINV events were recorded using a CINV diary. Pharmacoinformatics analysis involved principal component analysis of 12 risk factors to differentiate patients with and without complete response (CR), complete protection (CP) and complete control (CC). Results: 710 patients were recruited. Mean age was 52.9±10.3 years. Majority were females (67%) and Chinese (84%). Patient proportions that achieved CR, CP and CC were 58%, 42% and 27% respectively. Five risk factors were identified as potential predictors of these endpoints. Period of alcohol drinking and history of CIV were predictive in cisplatin-based regimens, while drinking frequency and history of CIN were predictive in anthracycline-based and oxaliplain-based regimens. Fatigue interference was a better predictor than severity generally Conclusions: This study has successfully utilized a pharmacoinformatics tool to pinpoint 5 clinical predictors in patients whose CINV are not well managed. Future research should further optimize antiemetic therapies in these populations.

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