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Utilizing a pharmacoinformatics tool for the prediction of chemotherapy-induced nausea and vomiting in Asian patients on emetogenic chemotherapies
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Yap, Kevin Yi-Lwern, Low, Xiu Hui and Chan, Alexandre (2011) Utilizing a pharmacoinformatics tool for the prediction of chemotherapy-induced nausea and vomiting in Asian patients on emetogenic chemotherapies. Supportive Care In Cancer, Vol.19 (Suppl.2). S110-S111. doi:10.1007/s00520-011-1184-y
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Official URL: http://dx.doi.org/10.1007/s00520-011-1184-y
Abstract
Objectives: A pharmacoinformatics tool was employed in
this prospective, cohort study to determine its utility in
identifying risk factors that are useful as predictors of
chemotherapy-induced nausea and vomiting (CINV).
Methods: Asian patients on a variety of chemotherapy
regimens and appropriate antiemetic treatment were
recruited from January 2007–July 2010. CINV events were
recorded using a CINV diary. Pharmacoinformatics analysis involved principal component analysis of 12 risk factors to differentiate patients with and without complete response (CR), complete protection (CP) and complete control (CC).
Results: 710 patients were recruited. Mean age was 52.9±10.3 years. Majority were females (67%) and Chinese (84%). Patient proportions that achieved CR, CP and CC were 58%, 42% and 27% respectively. Five risk factors were identified as potential predictors of these endpoints. Period of alcohol drinking and history of CIV were predictive in cisplatin-based regimens, while drinking frequency and history of CIN were predictive in anthracycline-based and oxaliplain-based regimens. Fatigue interference was a better predictor than severity generally
Conclusions: This study has successfully utilized a pharmacoinformatics tool to pinpoint 5 clinical predictors in patients whose CINV are not well managed. Future research should further optimize antiemetic therapies in these populations.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science > WMG (Formerly the Warwick Manufacturing Group) | ||||
| Journal or Publication Title: | Supportive Care In Cancer | ||||
| Publisher: | Springer | ||||
| ISSN: | 0941-4355 | ||||
| Official Date: | 2011 | ||||
| Dates: |
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| Volume: | Vol.19 | ||||
| Number: | Suppl.2 | ||||
| Number of Pages: | 2 | ||||
| Page Range: | S110-S111 | ||||
| Identifier: | 10.1007/s00520-011-1184-y | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Version or Related Resource: | This item was originally presented at the 2011 International MASCC/ISOO Symposium, Athens, Greece, Jun 23-25, 2011 |
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