Yap, Kevin Yi-Lwern, Low, Xiu Hui and Chan, Alexandre. (2011) Utilizing a pharmacoinformatics tool for the prediction of chemotherapy-induced nausea and vomiting in Asian patients on emetogenic chemotherapies. Supportive Care In Cancer, Vol.19 (Suppl.2). S110-S111. ISSN 0941-4355

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Abstract

Objectives: A pharmacoinformatics tool was employed in this prospective, cohort study to determine its utility in identifying risk factors that are useful as predictors of chemotherapy-induced nausea and vomiting (CINV). Methods: Asian patients on a variety of chemotherapy regimens and appropriate antiemetic treatment were recruited from January 2007–July 2010. CINV events were recorded using a CINV diary. Pharmacoinformatics analysis involved principal component analysis of 12 risk factors to differentiate patients with and without complete response (CR), complete protection (CP) and complete control (CC). Results: 710 patients were recruited. Mean age was 52.9±10.3 years. Majority were females (67%) and Chinese (84%). Patient proportions that achieved CR, CP and CC were 58%, 42% and 27% respectively. Five risk factors were identified as potential predictors of these endpoints. Period of alcohol drinking and history of CIV were predictive in cisplatin-based regimens, while drinking frequency and history of CIN were predictive in anthracycline-based and oxaliplain-based regimens. Fatigue interference was a better predictor than severity generally Conclusions: This study has successfully utilized a pharmacoinformatics tool to pinpoint 5 clinical predictors in patients whose CINV are not well managed. Future research should further optimize antiemetic therapies in these populations.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Science > WMG (Formerly the Warwick Manufacturing Group)
Journal or Publication Title:	Supportive Care In Cancer
Publisher:	Springer
ISSN:	0941-4355
Date:	2011
Volume:	Vol.19
Number:	Suppl.2
Number of Pages:	2
Page Range:	S110-S111
Identification Number:	10.1007/s00520-011-1184-y
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Version or Related Resource:	This item was originally presented at the 2011 International MASCC/ISOO Symposium, Athens, Greece, Jun 23-25, 2011
URI:	http://wrap.warwick.ac.uk/id/eprint/47850

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