Cheung, Yin Ting, Yap, Kevin Yi-Lwern, Chui, Wai Keung and Chan, Alexandre. (2010) Drug-drug interactions between oral antiepileptics and oral anticancer drugs: implications to clinicians. European Neurology, Vol.64 (No.2). pp. 88-94. ISSN 0014-3022

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Abstract

Background: Existing research has suggested that there can be potential drug-drug interaction (DDI) between antiepileptic drugs (AED) and anticancer drugs (ACD). However, information on the prevalence of patients on concurrent oral AED and oral ACD is limited. Methods: A retrospective study was conducted at the National Cancer Centre Singapore. Prevalence was calculated by identifying prescriptions with both oral AED and oral ACD from the outpatient prescription database over three years. Prevalence and physicians’ prescribing patterns were evaluated. Co-prescription was defined as medications that were prescribed by the same physician on the same day. Potentially interacting combinations were further detected using an existing database, OncoRx (www.onco-informatics.com). Results: 42,810 prescriptions that contained at least one oral ACD were identified from the database. The number and prevalence of prescriptions that had a combination of oral ACD and AED were 274 and 0.64%, respectively, with the majority (82.8%) of the AED-oral ACD pairs being co-prescribed. Per patient, the average number of exposure days to the AED-oral ACD pair was 19.5 days annually. Fifty-one (18.6%) prescriptions were identified as containing potentially interacting AED-oral ACD pairs. Discussion: There is a relatively low prevalence of AED-oral ACD combined exposure in the population we sampled; however, the combined exposure is long enough to produce clinically important DDI effects.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Science > WMG (Formerly the Warwick Manufacturing Group)
Journal or Publication Title:	European Neurology
Publisher:	S. Karger AG
ISSN:	0014-3022
Date:	August 2010
Volume:	Vol.64
Number:	No.2
Number of Pages:	7
Page Range:	pp. 88-94
Identification Number:	10.1159/000315031
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Faculty of Science, National University of Singapore , Department of Pharmacy, National University of Singapore
Grant number:	R-148-000-108-133 (FoS, NUoS)
URI:	http://wrap.warwick.ac.uk/id/eprint/47867

Data sourced from Thomson Reuters' Web of Knowledge

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