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Cancer informatics for the clinician: an interaction database for chemotherapy regimens and antiepileptic drugs
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Yap, Kevin Yi-Lwern, Chan, Alexandre, Chui, Wai Keung and Chen, Yu Zong (2010) Cancer informatics for the clinician: an interaction database for chemotherapy regimens and antiepileptic drugs. Seizure - European Journal of Epilepsy, Vol.19 (No.1). pp. 59-67. doi:10.1016/j.seizure.2009.11.004 ISSN 1059-1311.
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Official URL: http://dx.doi.org/10.1016/j.seizure.2009.11.004
Abstract
Background
Cancer patients are at high risks of manifesting drug–drug interactions (DDIs) which can potentiate serious negative outcomes. It is important for clinicians to make accurate, timely, safe and effective decisions with regards to drug use in the patient.
Objective
To provide clinicians with an oncology-specific drug interaction database that is relevant to their daily practice. This database focuses on DDIs with anticancer drugs (ACDs), single- and multiple-agent chemotherapy regimens.
Methods
Drug-related and interaction-related information between anticancer and antiepileptic drugs were compiled from drug information handbooks and databases, package inserts, and published literature from PubMed. Web documents were served from a modified web server with a database engine and programming interface constructed using Adobe software and various programming scripts.
Results
OncoRx is an oncology-specific database whose structure is designed around chemotherapy regimens and generic drug names used in anticancer treatment. OncoRx currently comprises of 117 ACDs and 256 single-agent and combination chemotherapy regimens. It covers all the major classes of ACDs and their frequently prescribed chemotherapy regimens, and can detect up to over 2000 interactions with 24 antiepileptic drugs. Data provided to clinicians include pharmacokinetic parameters of the drugs, information regarding the chemotherapy regimens and the detected DDIs.
Conclusion
OncoRx is able to identify DDIs between ACDs and adjuvant drug therapy. This is the first database of its kind to be able to detect interactions for combination chemotherapy regimens. This tool will assist clinicians in improving clinical response and reducing adverse effects based on the therapeutic and toxicity profiles of the drugs.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology Z Bibliography. Library Science. Information Resources > ZA Information resources > ZA4450 Databases |
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| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||
| Journal or Publication Title: | Seizure - European Journal of Epilepsy | ||||
| Publisher: | Elsevier Ltd | ||||
| ISSN: | 1059-1311 | ||||
| Official Date: | January 2010 | ||||
| Dates: |
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| Volume: | Vol.19 | ||||
| Number: | No.1 | ||||
| Number of Pages: | 9 | ||||
| Page Range: | pp. 59-67 | ||||
| DOI: | 10.1016/j.seizure.2009.11.004 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||
| Funder: | National University of Singapore |
Data sourced from Thomson Reuters' Web of Knowledge
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