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11q13 is a susceptibility locus for hormone receptor positive breast cancer
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(2012) 11q13 is a susceptibility locus for hormone receptor positive breast cancer. Human Mutation, Vol.33 (No.7). pp. 1123-1132. doi:10.1002/humu.22089 ISSN 1059-7794.
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Official URL: http://dx.doi.org/10.1002/humu.22089
Abstract
A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P ≤ 3 × 10−9) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 × 10−39). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype. Hum Mutat 33:1123–1132, 2012.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Human Mutation | ||||
Publisher: | John Wiley & Sons Ltd. | ||||
ISSN: | 1059-7794 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | Vol.33 | ||||
Number: | No.7 | ||||
Page Range: | pp. 1123-1132 | ||||
DOI: | 10.1002/humu.22089 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Data sourced from Thomson Reuters' Web of Knowledge
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