Landay, Alan L., Stradling, Clare, Chen, Y-F. (Yen-Fu), Russell, Tracy, Connock, M., Thomas, G. Neil and Taheri, S.. (2012) The effects of dietary intervention on HIV dyslipidaemia : a systematic review and meta-analysis. PLoS ONE, Vol.7 (No.6). e38121. ISSN 1932-6203

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Abstract

Background Efficacy of dietary intervention for treatment and prevention of HIV-related lipid disturbances has not been well established. Methods We conducted a systematic search of electronic databases supplemented with manual searches and conference abstracts, without language restriction. All randomised controlled trials (RCTs) with blood lipid outcomes, involving dietary intervention or supplementation for the treatment or prevention of adult HIV dyslipidaemia, versus no or other intervention were included. Two authors using predefined data fields, including study quality indicators, extracted data independently. Results Eighteen studies (n = 873) met our inclusion criteria. Seven RCTs for omega-3 supplementation (n = 372), and four RCTs for dietary intervention (n = 201) were meta-analysed using random-effects models. Mild statistical heterogeneity was observed. Dietary intervention reduced triglyceride levels by −0·46 mmol/l (95%CI: −0·85 to −0·07 mmol/l) compared to control. Omega-3 supplementation reduced triglyceride levels by −1.12 mmol/l, (95%CI: −1·57 to −0·67 mmol/l) and total cholesterol, −0·36 mmol/l (95%CI: −0·67 to −0·05 mmol/l) compared to placebo/control. Conclusions Both omega-3 supplementation and dietary intervention reduced triglyceride level, with the latter possibly to a smaller extent. While dietary interventions are beneficial, more stringent dietary approaches may be necessary to fully address lipid disturbances in HIV patients.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences
Library of Congress Subject Headings (LCSH):	Blood lipids, HIV infections -- Complications -- Diet therapy
Journal or Publication Title:	PLoS ONE
Publisher:	PLOS
ISSN:	1932-6203
Date:	2012
Volume:	Vol.7
Number:	No.6
Page Range:	e38121
Identification Number:	10.1371/journal.pone.0038121
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access
Funder:	National Institute for Health Research (Great Britain) (NIHR), Developing Research Leadership, Capability and Capacity amongst Nurses, Midwives and Allied Health Professionals in the West Midlands
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URI:	http://wrap.warwick.ac.uk/id/eprint/48087

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