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Hierarchically structured titanium foams for tissue scaffold applications
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Singh, R., Lee, P. D., Jones, J. R., Poologasundarampillai, G., Post, T., Lindley, T. C. and Dashwood, R. J. (2010) Hierarchically structured titanium foams for tissue scaffold applications. Acta Biomaterialia, Vol.6 (No.12). pp. 4596-4604. doi:10.1016/j.actbio.2010.06.027 ISSN 1742-7061.
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Official URL: http://dx.doi.org/10.1016/j.actbio.2010.06.027
Abstract
We present a novel route for producing a new class of titanium foams for use in biomedical implant applications. These foams are hierarchically porous, with both the traditional large (>300 mu m) highly interconnected pores and, uniquely, wall struts also containing micron scale (0.5-5 mu m) interconnected porosities. The fabrication method consists of first producing a porous oxide precursor via a gel casting method, followed by electrochemical reduction to produce a metallic foam. This method offers the unique ability to tailor the porosity at several scales independently, unlike traditional space-holder techniques. Reducing the pressure during foam setting increased the macro-pore size. The intra-strut pore size (and percentage) can be controlled independently of macro-pore size by altering the ceramic loading and sintering temperature during precursor production. Typical properties for an 80% porous Ti foam were a modulus of similar to 1 GPa, a yield strength of 8 MPa and a permeability of 350 Darcies, all of which are in the range required for biomedical implant applications. We also demonstrate that the micron scale intra-strut porosities can be exploited to allow infiltration of bioactive materials using a novel bioactive silica-polymer composite, resulting in a metal-bioactive silica-polymer composite. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||
Journal or Publication Title: | Acta Biomaterialia | ||||
Publisher: | Elsevier Science Ltd. | ||||
ISSN: | 1742-7061 | ||||
Official Date: | December 2010 | ||||
Dates: |
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Volume: | Vol.6 | ||||
Number: | No.12 | ||||
Number of Pages: | 9 | ||||
Page Range: | pp. 4596-4604 | ||||
DOI: | 10.1016/j.actbio.2010.06.027 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | EC |
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