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Cognitive dysfunction in psychiatric disorders : characteristics, causes and the quest for improved therapy
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(2012) Cognitive dysfunction in psychiatric disorders : characteristics, causes and the quest for improved therapy. Nature Reviews Drug Discovery, Vol.11 (No.2). pp. 141-168. doi:10.1038/nrd3628 ISSN 1474-1776.
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Official URL: http://dx.doi.org/10.1038/nrd3628
Abstract
Studies of psychiatric disorders have traditionally focused on emotional symptoms such as depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are equally prominent and severely compromise quality of life, including social and professional integration. Consequently, intensive efforts are being made to characterize the cellular and cerebral circuits underpinning cognitive function, define the nature and causes of cognitive impairment in psychiatric disorders and identify more effective treatments. Successful development will depend on rigorous validation in animal models as well as in patients, including measures of real-world cognitive functioning. This article critically discusses these issues, highlighting the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science Faculty of Science, Engineering and Medicine > Engineering > Engineering |
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Journal or Publication Title: | Nature Reviews Drug Discovery | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 1474-1776 | ||||
Official Date: | February 2012 | ||||
Dates: |
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Volume: | Vol.11 | ||||
Number: | No.2 | ||||
Page Range: | pp. 141-168 | ||||
DOI: | 10.1038/nrd3628 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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