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Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer-systematic review and meta-analysis of trends by time and region

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Mehanna, Hisham M., Beech, Tom, Nicholson, Tom, El-Hariry, Iman, McConkey, Christopher C., Paleri, Vinidh, Roberts, Sally and Eisele, David W. (2012) Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer-systematic review and meta-analysis of trends by time and region. Head & Neck, Volume 35 (Number 5). pp. 747-755. doi:10.1002/hed.22015

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Official URL: http://dx.doi.org/10.1002/hed.22015

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Abstract

Background
Little information has been reported on regional and time trends of human papillomavirus (HPV) prevalence rates of oropharyngeal cancer (OPC) and non-OPC.

Methods
The study consisted of a systematic review and meta-analysis using random effects logistic regression models.

Results
Overall HPV prevalence in OPC (47.7%; 95% confidence interval [CI], 42.9–52.5%) increased significantly over time: from 40.5% (95% CI, 35.1–46.1) before 2000, to 64.3% (95% CI, 56.7–71.3) between 2000 and 2004, and 72.2% (95% CI, 52.9–85.7) between 2005 and 2009 (p < .001). Prevalence increased significantly in North America and Europe, and the significant gap between them that existed before 2000 (50.7% vs 35.3%, respectively, p = .008) has now disappeared (69.7% vs 73.1%, respectively, p = .8). Prevalence in non-OPC (21.8%; 95% CI, 18.9–25.1%) has not increased over time (p = .97)

Conclusions
The sharp increase in the proportion of HPV-positive OPC over the last decade has occurred at a faster rate in Europe compared with that in North America. In contrast, the relatively low prevalence of HPV in non-OPC remains unchanged.

Item Type: Journal Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Head & Neck
Publisher: John Wiley & Sons Ltd.
ISSN: 1043-3074
Official Date: May 2012
Dates:
DateEvent
May 2012Published
Volume: Volume 35
Number: Number 5
Page Range: pp. 747-755
DOI: 10.1002/hed.22015
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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