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Jenkins, H. R., Murch, Simon and Beattie, R. M. (2012) Diagnosing coeliac disease. Archives of Disease in Childhood, Vol.97 (No.5). pp. 393-394. doi:10.1136/archdischild-2011-301198
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Official URL: http://dx.doi.org/10.1136/archdischild-2011-301198
Abstract
Guidelines from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) for diagnosis and treatment of coeliac disease (CD) have not been revisited for 20 years. During this time, the perception of CD has changed from a rather uncommon enteropathy presenting in childhood, with obvious gastrointestinal symptoms, to a much more common multiorgan disease with a strong genetic predisposition (mainly associated with human leucocyte antigen (HLA)-DQ2 and HLA-DQ8). Previous ESPGHAN diagnostic criteria1 stated that histological confirmation of the typical changes of CD in the small intestine were mandatory for diagnosis and that a gluten challenge, and rebiopsy would need to be performed in those children under the age of 2 years diagnosed as having CD.
Since that time, largely because of the increasing availability of specific serological testing, it has become clear that CD may present with a large variety of non-specific signs and symptoms, rather than a specific gastrointestinal presentation.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) | ||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Archives of Disease in Childhood | ||||
| Publisher: | BMJ | ||||
| ISSN: | 0003-9888 | ||||
| Official Date: | May 2012 | ||||
| Dates: |
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| Volume: | Vol.97 | ||||
| Number: | No.5 | ||||
| Page Range: | pp. 393-394 | ||||
| DOI: | 10.1136/archdischild-2011-301198 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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