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High-affinity glycopolymer binding to human DC-SIGN and disruption of DC-SIGN interactions with HIV envelope glycoprotein

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Becer, C. Remzi, Gibson, Matthew I., Geng, Jin, Ilyas, Rebecca, Wallis, Russell, Mitchell, Daniel Anthony and Haddleton, David M.. (2010) High-affinity glycopolymer binding to human DC-SIGN and disruption of DC-SIGN interactions with HIV envelope glycoprotein. Journal of the American Chemical Society, Vol.132 (No.43). pp. 15130-15132. ISSN 0002-7863

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Abstract

Noncovalent interactions between complex carbohydrates and proteins drive many fundamental processes within biological systems, including human immunity. In this report we aimed to investigate the potential of mannose-containing glycopolymers to interact with human DC-SIGN and the ability of these glycopolymers to inhibit the interactions between DC-SIGN and the HIV envelope glycoprotein gp120. We used a library of glycopolymers that are prepared via combination of copper-mediated living radical polymerization and azide alkyne-alkyne [3+2] Huisgen cycloaddition reaction. We demonstrate that a relatively simple glycopolymer can effectively prevent the interactions between a human dendritic cell associated lectin (DC-SIGN) and the viral envelope glycoprotein gp120. This approach may give rise to novel insights into the mechanisms of HIV infection and provide potential new therapeutics.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Polymerization, Glycoproteins, Glycomics, Viral envelopes
Journal or Publication Title: Journal of the American Chemical Society
Publisher: American Chemical Society
ISSN: 0002-7863
Official Date: 3 November 2010
Volume: Vol.132
Number: No.43
Number of Pages: 3
Page Range: pp. 15130-15132
Identification Number: 10.1021/ja1056714
Status: Peer Reviewed
Publication Status: Published
Funder: European Union (EU), University of Warwick, Wellcome Trust (London, England)
Grant number: 235999 (EU), 077400 (WT)
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URI: http://wrap.warwick.ac.uk/id/eprint/4842

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