Unterkofler, S., McQuitty, Ruth J., Euser, T. G., Farrer, Nicola J., Sadler, P. J. and Russell, P. St.J.. (2012) Microfluidic integration of photonic crystal fibers for online photochemical reaction analysis. Optics Letters, Vol. 37 (No. 11). pp. 1952-1954. ISSN 0146-9592

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Abstract

Liquid-filled hollow-core photonic crystal fibers (HC-PCFs) are perfect optofluidic channels, uniquely providing low-loss optical guidance in a liquid medium. As a result, the overlap of the dissolved specimen and the intense light field in the micronsized core is increased manyfold compared to conventional bioanalytical techniques, facilitating highly-efficient photoactivation processes. Here we introduce a novel integrated analytical technology for photochemistry by microfluidic coupling of a HC-PCF nanoflow reactor to supplementary detection devices. Applying a continuous flow through the fiber, we deliver photochemical reaction products to a mass spectrometer in an online and hence rapid fashion, which is highly advantageous over conventional cuvette-based approaches.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Photochemistry, Microfluidics, Photonics, Crystal optics, Fiber optics
Journal or Publication Title:	Optics Letters
Publisher:	Optical Society of America
ISSN:	0146-9592
Date:	2012
Volume:	Vol. 37
Number:	No. 11
Page Range:	pp. 1952-1954
Identification Number:	10.1364/OL.37.001952
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Körber-Stiftung, European Regional Development Fund (ERDF), Advantage West Midlands (AWM), Engineering and Physical Sciences Research Council (EPSRC), University of Warwick. Molecular Organisation and Assembly in Cells, European Research Council (ERC)
Grant number:	EP/G006792 (EPSRC), 247450 (ERC)
References:	1. C. Monat, P. Domachuk, and B. J. Eggleton, "Integrated optofluidics: A new river of light," Nature Phot. 1, 106 (2007). 2. X. Fan and I. M. White, "Optofluidic microsystems for chemical and biological analysis," Nature Phot. 5, 591– 597 (2011). 3. P. St.J. Russell, "Photonic crystal fibers," Science 299, 358– 362 (2003). 4. J. S. Y. Chen, T. G. Euser, N. J. Farrer, P. J. Sadler, and P. St.J. Russell, "Photochemistry in photonic crystal fiber nanoreactors," Chem. Eur. J. 16, 5607–5612 (2010). 5. A. M. Cubillas, M. Schmidt, M. Scharrer, T. G. Euser, B. J. Etzold, N. Taccardi, P. Wasserscheid, and P. St.J. Russell, "Ultra-low concentration monitoring of catalytic reactions in photonic crystal fiber," Chem. Eur. J. 18, 1586-1590 (2012). 6.W. J. Griffiths, A. P. Jonsson, S. Liu, D. K. Rai, and Y. Wang, "Electrospray and tandem mass spectrometry in biochemistry," Biochem. J. 355, 545–561 (2001). 7. J. M. Pratt, "The chemistry of vitamin B12. Part II. Photochemical reactions," J. Chem Soc. pp. 5154–5160 (1964). 8. N. J. Farrer, L. Salassa, and P. J. Sadler, “Photoactivated chemotherapy (PACT): the potential of excited-state dblock metals in medicine ,” Dalton Trans. 48, 10690-10701 (2009). 9. M. Brivio, R. H. Fokkens, W. Verboom, D. N. Reinhoudt, N. R. Tas, M. Goedbloed, and A. van den Berg, "Integrated microfluidic system enabling (bio)chemical reactions with on-line MALDI-TOF-mass spectrometry," Anal. Chem. 74, 3972–3976 (2002). 10. R. D. Oleschuk and D. J. Harrison, "Analytical microdevices for mass spectrometry," Trends Anal. Chem. 19, 379-388 (2000).
URI:	http://wrap.warwick.ac.uk/id/eprint/48498

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