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Refinement of the clinical scenario evaluation framework for assessment of competing development strategies with an application to multiple sclerosis

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Friede, Tim, Nicholas, Richard, Stallard, Nigel, Todd, Susan, Parsons, Nicholas R., Valdes-Marquez, Elsa and Chataway, J. (2010) Refinement of the clinical scenario evaluation framework for assessment of competing development strategies with an application to multiple sclerosis. Drug Information Journal, Vol.44 (No.6). pp. 713-718. doi:10.1177/009286151004400607

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Official URL: http://dx.doi.org/10.1177/009286151004400607

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Abstract

When competing strategies for development programs, clinical trial designs, or data analysis methods exist, the alternatives need to be evaluated in a systematic way to facilitate informed decision making. Here we describe a refinement of the recently proposed clinical scenario evaluation framework for the assessment of competing strategies. The refinement is achieved by subdividing key elements previously proposed into new categories, distinguishing between quantities that can be estimated from preexisting data and those that cannot and between aspects under the control of the decision maker from those that are determined by external constraints. The refined framework is illustrated by an application to a design project for an adaptive seamless design for a clinical trial in progressive multiple sclerosis.

Item Type: Journal Article
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Drug development -- Research, Multiple sclerosis, Clinical trials -- Design, Clinical trials -- Methodology
Journal or Publication Title: Drug Information Journal
Publisher: Drug Information Association
ISSN: 0092-8615
Official Date: November 2010
Dates:
DateEvent
November 2010Published
Volume: Vol.44
Number: No.6
Number of Pages: 6
Page Range: pp. 713-718
DOI: 10.1177/009286151004400607
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: National Institute for Health Research (Great Britain) (NIHR), MS Society of Great Britain and Northern Ireland (MSS)
Grant number: 878/08, 913/09

Data sourced from Thomson Reuters' Web of Knowledge

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