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Refinement of the clinical scenario evaluation framework for assessment of competing development strategies with an application to multiple sclerosis
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Friede, Tim, Nicholas, Richard, Stallard, Nigel, Todd, Susan, Parsons, Nicholas R., Valdes-Marquez, Elsa and Chataway, J.. (2010) Refinement of the clinical scenario evaluation framework for assessment of competing development strategies with an application to multiple sclerosis. Drug Information Journal, Vol.44 (No.6). pp. 713-718. ISSN 0092-8615
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Official URL: http://dx.doi.org/10.1177/009286151004400607
Abstract
When competing strategies for development programs, clinical trial designs, or data analysis methods exist, the alternatives need to be evaluated in a systematic way to facilitate informed decision making. Here we describe a refinement of the recently proposed clinical scenario evaluation framework for the assessment of competing strategies. The refinement is achieved by subdividing key elements previously proposed into new categories, distinguishing between quantities that can be estimated from preexisting data and those that cannot and between aspects under the control of the decision maker from those that are determined by external constraints. The refined framework is illustrated by an application to a design project for an adaptive seamless design for a clinical trial in progressive multiple sclerosis.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Drug development -- Research, Multiple sclerosis, Clinical trials -- Design, Clinical trials -- Methodology |
| Journal or Publication Title: | Drug Information Journal |
| Publisher: | Drug Information Association |
| ISSN: | 0092-8615 |
| Official Date: | November 2010 |
| Volume: | Vol.44 |
| Number: | No.6 |
| Number of Pages: | 6 |
| Page Range: | pp. 713-718 |
| Identification Number: | 10.1177/009286151004400607 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | National Institute for Health Research (Great Britain) (NIHR), MS Society of Great Britain and Northern Ireland (MSS) |
| Grant number: | 878/08, 913/09 |
| URI: | http://wrap.warwick.ac.uk/id/eprint/4864 |
Data sourced from Thomson Reuters' Web of Knowledge
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