Stallard, Nigel and Friede, Tim (2011) Efficiency of adaptive designs. In: Pong, Annpey and Chow, Shein-Chung, (eds.) Handbook of adaptive designs in pharmaceutical and clinical development. Boca Raton: CRC Press. ISBN 9781439810163

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Abstract

This comprehensive guide offers a unified presentation of the principles and methodologies in adaptive design and analysis. It gives a well-balanced summary of current regulatory perspectives and recently developed statistical methods in this area. The handbook provides some insight regarding early phase and later phase adaptive designs. With a focus on the implementation of adaptive methods in clinical trials, it introduces the concepts of role, responsibility, function, and activity of a data safety monitoring board (DSMB) when applying these methods. Other important topics covered in detail include regulatory perspectives and logistics issues in applying adaptive design methods.

Item Type:	Book Item
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School
Publisher:	CRC Press
Place of Publication:	Boca Raton
ISBN:	9781439810163
Book Title:	Handbook of adaptive designs in pharmaceutical and clinical development
Editor:	Pong, Annpey and Chow, Shein-Chung
Date:	2011
Status:	Peer Reviewed
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/48666

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